4.5 Article

Monitoring inflammation in psychiatry: Caveats and advice

Journal

EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 54, Issue -, Pages 126-135

Publisher

ELSEVIER
DOI: 10.1016/j.euroneuro.2021.09.003

Keywords

Cytokines; Blood Biomarkers; Bipolar disorders; Depression; schizophrenia

Funding

  1. Agence Nationale de la Recherche
  2. Universite Cote d'Azur
  3. Stanley Medical Research Institute

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Most researchers in immunopsychiatry agree that severe psychiatric disorders are linked to inflammation and changes in immune variables. However, the field is facing a replication crisis due to lack of reproducibility. Current studies focus on immune variables in blood and discuss analytical methods and overlooked methodological issues.
Most researchers working in the field of immunopsychiatry would agree with the statement that severe psychiatric disorders are associated with inflammation and more broadly with changes in immune variables. However, as many other fields in biology and medicine, immunopsychiatry suffers from a replication crisis characterized by lack of reproducibility. In this paper, we will comment on four types of immune variables which have been studied in psychiatric disorders: Acute Phase Proteins (AAPs), cytokines, lipid mediators of inflammation and immune cell parameters, and discuss the rationale for looking at them in blood. We will briefly describe the analytical methods that are currently used to measure the levels of these biomarkers and comment on overlooked analytical and statistical methodological issues that may explain some of the conflicting data reported in the literature. Lastly, we will briefly summarize what crosssectional, longitudinal and mendelian randomization studies have brought to our understanding of schizophrenia (SZ).

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