4.7 Article

NAAA inhibitor F96 attenuates BBB disruption and secondary injury after traumatic brain injury (TBI)

Journal

EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 912, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.ejphar.2021.174561

Keywords

Traumatic brain injury (TBI); N-Acylethanolamine acid amidase (NAAA); Palmitoylethanolamide (PEA); Blood -brain barrier (BBB); Peroxisome proliferator activated receptor alpha (PPAR alpha)

Funding

  1. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
  2. Key Program of Frontier Science, CAS [QYZDJ-SSW-SLH033]
  3. Xiamen Science and Technology Program Project [3502Z20203085]
  4. National Natural Science Foundation of China [81602974]
  5. Natural Science Foundation of Fujian Province [2018J05145]
  6. Key laboratory of functional and clinical translational medicine, Fujian province university [XMMC-FCTM201904]

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TBI induced an increase in PEA levels, preventing BBB disruption, but NAAA facilitated PEA degradation through neutrophils, weakening the BBB protective effects and exacerbating tissue injury.
Traumatic brain injury (TBI) is a leading cause of death worldwide, for which there is currently no comprehensive treatment available. Preventing blood-brain barrier (BBB) disruption is crucial for TBI treatment. Nacylethanolamine acid amidase (NAAA)-regulated palmitoylethanolamide (PEA) signaling play an important role in the control of inflammation. However, the role of NAAA in BBB dysfunction following TBI remains unclear. In the present study, we found that TBI induces the increase of PEA levels in the injured cortex, which prevent the disruption of BBB after TBI. TBI also induces the infiltration of NAAA-contained neutrophils, increasing the contribution of NAAA to the PEA degradation. Neutrophil-derived NAAA weakens PEA/PPAR alpha-mediated BBB protective effects after TBI, facilitates the accumulation of immune cells, leading to secondary expansion of tissue injury. Inactivation of NAAA increased PEA levels in injured site, prevents early BBB damage and improves secondary injury, thereby eliciting long-term functional improvements after TBI. This study identified a new role of NAAA in TBI, suggesting that NAAA is a new important target for BBB dysfunction related CNS diseases.

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