4.7 Article

Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Cell Biology

Huaier shows anti-cancer activities by inhibition of cell growth, migration and energy metabolism in lung cancer through PI3K/AKT/HIF-1α pathway

Xiangli Liu et al.

Summary: The study found that Huaier, through inhibiting cell viability and migration, suppressing glycolysis and lactic acid accumulation, was able to reduce NSCLC tumor volume and growth. In addition, intervention in the PI3K/AKT/HIF-1 alpha pathway may be one of the mechanisms by which Huaier exhibits its anti-tumor effects.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth

Rosalin Mishra et al.

Summary: RIDR-PI-103 is a novel prodrug that releases PI-103 in a controlled manner under high ROS conditions to inhibit PI3K. It demonstrates cytotoxicity in breast cancer cells and when combined with doxorubicin, can suppress cancer cell growth and proliferation. Pharmacokinetic studies in mice show promising results for potential therapeutic use in breast cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

Saleh A. Almatroodi et al.

Summary: Polyphenolic flavonoids, especially Quercetin, exhibit potent antioxidant and anticancer properties. Quercetin can target specific molecular signaling pathways involved in cancer progression and has shown promising therapeutic potential in various types of cancers. More research is needed to fully understand the exact mechanism of action of Quercetin in cancer treatment.

MOLECULES (2021)

Article Chemistry, Medicinal

Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy

Rosalba Florio et al.

Summary: Repurposing of approved non-antitumor drugs provides a promising and cost-effective strategy to expand the repertoire of effective anticancer drugs. Benzimidazole-based anthelmintics, due to their antitumor activities, are being considered for repurposing in cancer therapy. In vitro studies have shown consistent antiproliferative effects of certain benzimidazole compounds on various tumor cell lines, with potential polypharmacology highlighted through in silico target prediction.

PHARMACEUTICALS (2021)

Review Biochemistry & Molecular Biology

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

Pankaj Sharma et al.

Summary: This review discusses recent studies on the use of imidazole/fused imidazole derivatives as anticancer agents. These molecules exhibit anticancer activity by modulating various targets, including some compounds with unknown mechanisms.

MOLECULES (2021)

Article Gastroenterology & Hepatology

Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine

Gregorio Di Franco et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Article Medicine, Research & Experimental

Anti-cancer activity of benzoxazinone derivatives via targeting c-Myc G-quadruplex structure

Shikun Jiang et al.

LIFE SCIENCES (2020)

Review Biochemistry & Molecular Biology

DNA damage kinase signaling: checkpoint and repair at 30 years

Michael Charles Lanz et al.

EMBO JOURNAL (2019)

Article Biotechnology & Applied Microbiology

Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway

Rui Wang et al.

ONCOTARGETS AND THERAPY (2019)

Review Pharmacology & Pharmacy

Lung Cancer Heterogeneity and New Strategies for Drug Therapy

Diane C. Wang et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Article Biotechnology & Applied Microbiology

Betulinic acid induces DNA damage and apoptosis in SiHa cells

Priya Goswami et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2018)

Article Public, Environmental & Occupational Health

Anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer

Qi Li et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2016)

Article Biochemistry & Molecular Biology

Microwave-assisted synthesis of phenanthroimidazole derivatives as stabilizer of c-myc G-quadruplex DNA

Siyan Liao et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2014)

Article Cell Biology

Existence and consequences of G-quadruplex structures in DNA

Pierre Murat et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)

Review Pharmacology & Pharmacy

Advances towards the design and development of personalized non-small-cell lung cancer drug therapy

Sabrina Vari et al.

EXPERT OPINION ON DRUG DISCOVERY (2013)

Article Biochemistry & Molecular Biology

High-mobility group box-1 protein induces mucin 8 expression through the activation of the JNK and PI3K/Akt signal pathways in human airway epithelial cells

Dong Eun Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)