Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 917, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2022.174754
Keywords
Glutamic oxaloacetic transaminase 1; Structure and function; Cancer; Small molecule inhibitors
Categories
Funding
- National Natural Science Foundation of China, China (NSFC) [81773594, 81773637, 81773869, U1803122]
- Liaoning Revitalization Talents Program [XLYC1807182]
- Chunhui Program-Cooperative Research Project of the Ministry of Education, Liaoning Province Natural Science Foundation, China [2020-MZLH-31, 2019-MS-299]
- Shenyang Young and Middle-aged Innovative Talents Support Program [RC210446]
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This review summarizes the structure and function of GOT1 and its important roles in cell proliferation and cancer progression, and also discusses the characteristics of GOT1 inhibitors. It provides new insights into the discovery of potential anti-GOT1 drugs for cancer treatment.
Glutamic Oxaloacetic Transaminase 1 (GOT1) is one distinct isoenzyme of glutamic oxaloacetic transaminase in eukaryotic cells, which is located in the cytoplasm. To date, several studies have shown that GOT1 plays a critical role in regulating cell proliferation by participating in amino acid metabolism, especially in glutamine metabolism. In addition, GOT1 is overexpressed in many cancer, so GOT1 has been identified as a potentially therapeutic target. Herein, this review summarizes the structure and function of GOT1 and the important roles of GOT1 in some tumor progress, as well as the characterization of GOT1 inhibitors. It may provide new insight into the discovery of small compounds as potential anti-GOT1 drugs for treatment of cancer.
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