Sustainable Mechanosynthesis of Biologically Active Molecules

Synthetic mechanochemistry, the use of mechanical force produced by milling, grinding or extruding, as an activation technique, provides access to chemical entities of all kinds. This Review is focused on examples reported so far of known Active Pharmaceutical Ingredients (APIs), and effectively evaluated bioactive molecules, all prepared by mechanosynthesis. Three families of molecules are discussed: heterocyclic compounds, metal complexes and peptides. Advantages of the mechanochemistry approach are highlighted especially from a green chemistry and efficacy point of view.

Automated summary

This Review focuses on the applications of synthetic mechanochemistry in the preparation of known APIs and evaluated bioactive molecules. Three families of compounds, including heterocyclic compounds, metal complexes, and peptides, are discussed. The advantages of mechanochemistry approach are highlighted in terms of green chemistry and efficacy.