Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 48, Pages 6764-6767Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202101330
Keywords
Cascade Reactions; Internal Alkynes; Naphthalenes; Nickel-catalyzed; o-Vinyl Chlorobenzenes
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Funding
- NSFC [21702035]
- Pearl River Talents Recruitment Program of Guangdong Province [2017GC010600]
- Science and Technology Program of Guangzhou [201804010455]
- High-level University Construction Fund of Guangdong Province [06-410-2107223]
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An efficient nickel-catalyzed arylnickelation/Heck cyclization reaction has been developed for the challenging synthesis of substituted naphthalenes from o-vinyl chlorobenzenes and internal alkynes. Mechanistic studies indicate that the radical pathway is not involved in this cascade catalytic system.
An efficient nickel-catalyzed arylnickelation of alkyne/Heck cyclization of challenging o-vinyl chlorobenzenes with internal alkynes has been developed. This protocol enables synthesis of a wide variety of substituted naphthalenes in a cascade process from readily available starting materials. Mechanistic studies indicate the radical pathway is not involved in the cascade catalytic system.
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