A review: Pharmacological aspects of metal based 1,2,4-triazole derived Schiff bases

Clinical reports have highlighted the radical increase of antibiotic resistance. As a result, multidrug resistance has emerged as a serious threat to human health. Many organic compounds commonly used as drugs in the past, no longer have pure organic mode of action rather need bio-transformation or more activation. Bulk of research has shown that they need trace amount of metal ions incorporated within the chemistry of bioactive molecules for enhancement of their potentiality to fight aggressively against resistance. The deficiency of some metal ions can also be responsible for many diseases like growth retardation, pernicious anemia and heart diseases in infants. To overcome these problems, there is a need to introduce novel strategies which have new mechanism of action along with significant spectrum of biological activity, enhanced safety and efficacy. Bioinorganic compounds have played imperative role in developing the new strategy in the form of Metal Based Drugs. In current years there have been momentous rise of interest in the application of metal based Schiff base compounds to treat various diseases which are difficult to be treated with conventional methodologies. The unique properties of metal chelates acting as an intermediate between conventional organic and inorganic compounds provided innovative opportunities in the field of pharmaceutical chemistry. In this review, we have exclusively focused on the search of metal based 1,2,4-triazole derived Schiff base compounds (synthesized, reported and reviewed in the past ten years) that possess various biological activities such as antifungal, antibacterial, antioxidant, antidiabetic, anthelmintic, anticancer, antiproliferative, cytotoxic and DNA-intercalation activity. (C) 2021 Elsevier Masson SAS. All rights reserved.

Automated summary

Clinical reports have emphasized the increasing threat of multidrug resistance due to antibiotic resistance. Research has shown that organic compounds now require metal ions for bio-transformation in order to enhance their potentiality against resistance. Metal based drugs have played an imperative role in developing new strategies with significant biological activity, safety, and efficacy. In recent years, metal based compounds have been of great interest for treating various diseases, filling the gap left by conventional methodologies.