4.7 Article

Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Malgorzata Krajewska et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Yang Gao et al.

CELL CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Tinghu Zhang et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Biotechnology & Applied Microbiology

The history and future of targeting cyclin-dependent kinases in cancer therapy

Uzma Asghar et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Multidisciplinary Sciences

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Nicholas Kwiatkowski et al.

NATURE (2014)

Review Biotechnology & Applied Microbiology

Cyclin-dependent kinases

Marcos Malumbres

GENOME BIOLOGY (2014)

Article Cell Biology

Targeting cyclin-dependent kinases in anti-neoplastic therapy

Celine Bruyere et al.

CURRENT OPINION IN CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

MultiBac: expanding the research toolbox for multiprotein complexes

Christoph Bieniossek et al.

TRENDS IN BIOCHEMICAL SCIENCES (2012)

Review Cell Biology

Cyclin K goes with Cdk12 and Cdk13

Jiri Kohoutek et al.

CELL DIVISION (2012)

Article Biochemistry & Molecular Biology

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

Matthew P. Patricelli et al.

CHEMISTRY & BIOLOGY (2011)

Article Biochemical Research Methods

XDS

Wolfgang Kabsch

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Letter Cell Biology

Cyclin-dependent kinases: a family portrait

Marcos Malumbres et al.

NATURE CELL BIOLOGY (2009)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)