Related references
Note: Only part of the references are listed.Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?
Angela De Simone et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy
Aurelien Beato et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
DYRK1A Inhibitors as Potential Therapeutics for β-Cell Regeneration for Diabetes
Kunal Kumar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Recent Advances in the Synthesis of β-Carboline Alkaloids
Timea Szabo et al.
MOLECULES (2021)
Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor
Kunal Kumar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Structure-Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation
Kunal Kumar et al.
MOLECULES (2020)
A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists
Wenwu Liu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology
Xiaowen Jiang et al.
CLINICAL AND TRANSLATIONAL MEDICINE (2020)
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood
Jean Quancard et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions
Jaclyn R. Patterson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease
Kushal Kumar et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors
Bin Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice
Shu-Ping Li et al.
FRONTIERS IN PHARMACOLOGY (2018)
DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspective
Ankita Pathak et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities
Jiangkun Dai et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation
Kunal Kumar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Why we need to implement intramolecular hydrogen-bonding considerations in drug discovery
Giulia Caron et al.
FUTURE MEDICINAL CHEMISTRY (2017)
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease
Sai-Sai Xie et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
Weiteng An et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors
Christophe Labriere et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core
Prasanna Sivaprakasam et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice
Dandan He et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications
Ramzi Abbassi et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing
Sarah E. Mennenga et al.
PHYSIOLOGY & BEHAVIOR (2015)
Synthesis and Antiviral and Fungicidal Activity Evaluation of β-Carboline, Dihydro-β-carboline, Tetrahydro-β-carboline Alkaloids, and Their Derivatives
Hongjian Song et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2014)
Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer's Disease Therapeutic Application
Pradip K. Kamat et al.
MOLECULAR NEUROBIOLOGY (2014)
The worldwide economic impact of dementia 2010
Anders Wimo et al.
ALZHEIMERS & DEMENTIA (2013)
Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
Rafael Leon et al.
MEDICINAL RESEARCH REVIEWS (2013)
Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β
Ludovic Martin et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites
Danielle Frost et al.
PLOS ONE (2011)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A
Yasushi Ogawa et al.
NATURE COMMUNICATIONS (2010)
Synthesis and antiviral activity of β-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1)
Anelise S. Nazari Formagio et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2009)
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease
Mark Hamann et al.
JOURNAL OF NATURAL PRODUCTS (2007)
High throughput artificial membrane permeability assay for blood-brain barrier
L Di et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)
Acetylcholinesterase in Alzheimer's disease
VN Talesa
MECHANISMS OF AGEING AND DEVELOPMENT (2001)
Alzheimer's disease: Genes, proteins, and therapy
DJ Selkoe
PHYSIOLOGICAL REVIEWS (2001)
Share Paper
