Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 226, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2021.113837
Keywords
Sulfonamide; Drug design; Anti-Cancer; Structure-activity relationships
Categories
Funding
- National Natural Science Foundation of China [82003602, 21877034]
- Natural Science Foundation of Hunan Province of China [2019JJ50145]
- Open Project Program of Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education [E22107]
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This review summarizes recent advances of sulfonamide derivatives as potential anti-cancer agents, focusing on their applications on anti-cancer targets and corresponding structure-activity relationships.
Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer agents are major challenges for cancer treatment, which energizes medicinal chemists to develop more anti-cancer agents with high efficiency and low toxicity continuously. Sulfonamide derivatives are a class of promising compounds with diverse biological activities including anti-cancer, and parts of them have been marketed for cancer therapy, such as Belinostat, ABT-199 and Amsacrine. In this review, we summed up the recent advances of sulfonamide derivatives as potential anti-cancer agents based on the anti-cancer targets, such as aromatase, carbonic anhydrase (CA), anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins, topoisomerase and phosphatidylinositol 3-kinase (PI3K), and elucidated the corresponding structure-activity relationships (SARs) of most sulfonamide derivatives. We hope this review could provide a clear insight for medicinal chemists in the rational design of more potent and bio-target specific anti-cancer agents. (C) 2021 Elsevier Masson SAS. All rights reserved.
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