The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Article Multidisciplinary Sciences

Improving reporting standards for polygenic scores in risk prediction studies

Hannah Wand et al.

Summary: Polygenic risk scores (PRSs) aggregate results from genome-wide association studies to estimate disease risk, but heterogeneity in their application and reporting hinders translation into clinical care. To address this, Polygenic Risk Score Reporting Standards (PRS-RS) have been proposed, providing a comprehensive framework to enhance the interpretation and evaluation of PRSs for downstream clinical applications. This structured format aims to promote data availability, transparency, and reproducibility, facilitating the progress towards defining best practice in the field.

NATURE (2021)

Add to Collection

Article Ethics

Polygenic risk scoring of human embryos: a qualitative study of media coverage

Tiny Pagnaer et al.

Summary: Analyzing 535 news articles revealed that 8.8% portrayed embryo polygenic scoring positively, 36.8% expressed negative attitudes, and 54.4% remained neutral. Main ethical themes identified included concerns about a slippery slope towards designer babies, child and parental well-being, societal impact, deliberate choice, and societal readiness.

BMC MEDICAL ETHICS (2021)

Add to Collection

Article Medicine, General & Internal

Problems with Using Polygenic Scores to Select Embryos

Patrick Turley et al.

Summary: Polygenic Embryo Selection In Vitro (ESPS) is a controversial genetic screening service that involves personalized predictions based on polygenic risk scores, but also raises debates over expected gains and potential unintended consequences. Responsible communication is essential, along with a need for a society-wide conversation about the implications of this technology.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Review Genetics & Heredity