Journal
EUROPEAN JOURNAL OF HAEMATOLOGY
Volume 108, Issue 6, Pages 493-502Publisher
WILEY
DOI: 10.1111/ejh.13758
Keywords
haematological neoplasms; immunity; humoral; immunoglobulin light chains; immunoglobulins; multiple myeloma; paraproteins; plasma cells; saliva
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This study investigated whether M-proteins and FLC can be detected in the saliva of myeloma patients and evaluated its utility for non-invasive screening and monitoring of hematological malignancies. The results showed that despite the elevated levels of M-proteins and FLC in the blood, only a few patients had detectable M-proteins in their saliva, and FLC almost did not enter the saliva. This suggests that saliva has limited value in the diagnosis of myeloma.
Objectives Myeloma is characterised by the presence of monoclonal immunoglobulin (M-protein) and the free light chain (FLC) in blood. We investigated whether these M-proteins and FLC are detectable in myeloma patients' saliva to evaluate its utility for non-invasive screening and monitoring of haematological malignancies. Methods A total of 57 patients with monoclonal gammopathy and 26 age-matched healthy participants provided paired serum and saliva samples for immunoglobulin characterisation and quantification. Results Myeloma patients had IgG or IgA M-protein levels ranging up to five times and FLC levels up to a thousand times normal levels of polyclonal immunoglobulins. Despite these highly elevated levels, only two IgG and no IgA M-proteins or FLC could be detected in paired saliva samples. Most patients had reduced levels of serum polyclonal immunoglobulins, but all had normal levels of salivary IgA. Conclusions Immunoglobulin transfer from blood is not determined by levels in the systemic circulation and more likely dictated by periodontal inflammation and the integrity of the oral epithelium. Immunoglobulins secreted by bone marrow plasma cells do not substantially enter saliva, which represents a poor medium for myeloma diagnosis. These findings, along with normal salivary IgA levels despite systemic immunoparesis, support a strong partitioning of oral from systemic humoral immunity.
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