4.6 Review

Oxidized phospholipids and lipoprotein(a): An update

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Atherothrombotic factors and atherosclerotic cardiovascular events: the multi-ethnic study of atherosclerosis

Andrew P. DeFilippis et al.

Summary: This study identified two new atherothrombotic factors that are significantly associated with incident ASCVD events, one representing thrombotic propensity and the other representing fibrinolytic propensity. These factors remained significantly associated with ASCVD events even after controlling for traditional risk factors.

EUROPEAN HEART JOURNAL (2022)

Editorial Material Cardiac & Cardiovascular Systems

Lipoprotein(a) reduction with proprotein convertase subtilisin/kexin type 9 inhibitors: An unsolved mystery

Evangelos Liberopoulos

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Lipoprotein(a) Reduction With Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Systematic Review and Meta-analysis

Ioannis Farmakis et al.

Summary: PCSK9 inhibitors have been shown to lower Lipoprotein(a) levels, with significant heterogeneity in their effects. Differences in comparator and treatment duration can influence the impact of PCSK9 inhibitors on Lipoprotein(a) levels.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Effect of bariatric surgery on plasma levels of oxidised phospholipids, biomarkers of oxidised LDL and lipoprotein(a)

Jan Hoong Ho et al.

Summary: Bariatric surgery leads to significant reduction in body mass index and positive effects on certain biomarkers of oxidized lipoproteins, while causing a significant increase in Lp(a) levels.

JOURNAL OF CLINICAL LIPIDOLOGY (2021)

Article Medical Laboratory Technology

Development of an LC-MS/MS Proposed Candidate Reference Method for the Standardization of Analytical Methods to Measure Lipoprotein(a)

Santica M. Marcovina et al.

Summary: The size polymorphism of apolipoprotein(a) affects immuno-chemical methods for lipoprotein(a) quantification. A LC-MS/MS method with a human recombinant apolipoprotein(a) reference material was developed, showing good accuracy, precision, and comparability, making it a potential candidate reference method for lipoprotein(a) standardization.

CLINICAL CHEMISTRY (2021)

Review Pharmacology & Pharmacy

Antidiabetic drugs and oxidized low-density lipoprotein: A review of anti-atherosclerotic mechanisms

Ali Ahmadi et al.

Summary: Cardiovascular disease is a leading cause of mortality globally, and diabetic patients are at a greater risk of developing atherosclerosis. Antidiabetic drugs exert various mechanisms to counter the undesirable effects of oxLDL, which can be extremely beneficial in controlling atherosclerosis in diabetic patients.

PHARMACOLOGICAL RESEARCH (2021)

Review Pharmacology & Pharmacy

Lipoprotein(a): Knowns, unknowns and uncertainties

Massimiliano Ruscica et al.

Summary: In the past decade, research has shown the association between high lipoprotein(a) levels and atherosclerotic cardiovascular diseases (ASCVD), although the impact of varying molar concentrations, apo(a) isoform size, and gene variants remains controversial. While single nucleotide polymorphisms that raise lipoprotein(a) have not been found to add predictive value for ASCVD beyond lipoprotein(a) concentrations, they are still a significant confounder in identifying familial hypercholesterolemia (FH). The ongoing outcome trial with pelacarsen aims to determine if dramatically lowering lipoprotein(a) levels can reduce the risk of ASCVD.

PHARMACOLOGICAL RESEARCH (2021)

Letter Cardiac & Cardiovascular Systems

PCSK9 Inhibition and Oxidized Phospholipids

Harpreet S. Bhatia et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Lp(a)-Associated Oxidized Phospholipids in Healthy Black and White Participants in Relation to apo(a) Size, Age, and Family Structure

Lars Berglund et al.

Summary: This study examined the relationship between Lp(a)-OxPL levels, Lp(a), apo(a) size, age, and family structure in two racial groups, revealing significant associations and differences in genetic characteristics and heritability estimates. Our findings suggest that OxPL levels are significantly associated with specific Lp(a) levels on different apo(a) sizes, with variations observed between Black and White participants.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Cardiac & Cardiovascular Systems

Satin therapy increases lipoprotein(a) levels

Sotirios Tsimikas et al.

EUROPEAN HEART JOURNAL (2020)

Article Cardiac & Cardiovascular Systems

ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis

Romain Capoulade et al.

HEART (2020)

Article Cardiac & Cardiovascular Systems

Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome

Vera A. Bittner et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Medicine, General & Internal

Lipoprotein(a) Reduction in Persons with Cardiovascular Disease

Sotirios Tsimikas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

The dedicated Lp(a) clinic: A concept whose time has arrived?

Sotirios Tsimikas et al.

ATHEROSCLEROSIS (2020)

Article Cardiac & Cardiovascular Systems

Lipoprotein(a) and PCSK9 inhibition: clinical evidence

Massimiliano Ruscica et al.

EUROPEAN HEART JOURNAL SUPPLEMENTS (2020)

Article Cardiac & Cardiovascular Systems

Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids

Calvin Yeang et al.

CARDIOVASCULAR RESEARCH (2019)

Review Cardiac & Cardiovascular Systems

y Phospholipid oxidation products in ferroptotic myocardial cell death

Aleksandra Stamenkovic et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Review Peripheral Vascular Disease

Current Role of Lipoprotein Apheresis

Gilbert Thompson et al.

CURRENT ATHEROSCLEROSIS REPORTS (2019)

Article Cardiac & Cardiovascular Systems

4945Inclisiran-mediated reductions in Lp(a) in the ORION-1 trial

R M Stoekenbroek et al.

EUROPEAN HEART JOURNAL (2019)

Article Cardiac & Cardiovascular Systems

Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk Insights From the FOURIER Trial

Michelle L. O'Donoghue et al.

CIRCULATION (2019)

Review Cardiac & Cardiovascular Systems

HEART UK consensus statement on Lipoprotein(a): A call to action

Jaimini Cegla et al.

ATHEROSCLEROSIS (2019)

Article Peripheral Vascular Disease

Actual situation of lipoprotein apheresis in patients with elevated lipoprotein(a) levels

Ulrich Julius et al.

ATHEROSCLEROSIS SUPPLEMENTS (2019)

Editorial Material Cardiac & Cardiovascular Systems

Lipoprotein(a): the perpetual supporting actor

Baris Gencer et al.

EUROPEAN HEART JOURNAL (2018)

Review Cardiac & Cardiovascular Systems

NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis

Sotirios Tsimikas et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Depicting new pharmacological strategies for familial hypercholesterolaemia involving lipoprotein (a)

Alpo Vuorio et al.

EUROPEAN HEART JOURNAL (2017)

Article Cardiac & Cardiovascular Systems

Lipoprotein(a): the revenant

Baris Gencer et al.

EUROPEAN HEART JOURNAL (2017)

Review Cardiac & Cardiovascular Systems

A Test in Context: Lipoprotein(a) Diagnosis, Prognosis, Controversies, and Emerging Therapies

Sotirios Tsimikas

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Article Hematology

Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease The Copenhagen General Population Study

Pia R. Kamstrup et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation

Olivier Friedli et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)

Review Immunology

The regulation of inflammation by oxidized phospholipids

Stefan Freigang

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

Article Pharmacology & Pharmacy

Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein (a)

Calvin Yeang et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2016)

Review Biochemistry & Molecular Biology

Thematic Review Series: Lipoprotein (a): Coming of Age at Last Lipoprotein apheresis to treat elevated lipoprotein (a)

Elisa Waldmann et al.

JOURNAL OF LIPID RESEARCH (2016)

Review Biochemistry & Molecular Biology

Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology

Borge G. Nordestgaard et al.

JOURNAL OF LIPID RESEARCH (2016)

Article Hematology

Heritability of Biomarkers of Oxidized Lipoproteins Twin Pair Study

Fangwen Rao et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Impact of Plasma Lp-PLA2 Activity on the Progression of Aortic Stenosis The PROGRESSA Study

Romain Capoulade et al.

JACC-CARDIOVASCULAR IMAGING (2015)

Article Pharmacology & Pharmacy

Pathophysiological Role and Clinical Significance of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Bound to LDL and HDL

Constantinos C. Tellis et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Medicine, General & Internal

Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease

Harvey D. White et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Pharmacology & Pharmacy

Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis

Gregor Leibundgut et al.

CURRENT OPINION IN PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Inflammatory Biomarkers and Cardiovascular Risk Assessment. Current Knowledge and Future Perspectives

Elisavet Moutzouri et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Review Medicine, General & Internal

Lipoprotein(a): resurrected by genetics

F. Kronenberg et al.

JOURNAL OF INTERNAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a)

Gregor Leibundgut et al.

JOURNAL OF LIPID RESEARCH (2013)

Article Cardiac & Cardiovascular Systems

Oxidation-Specific Biomarkers and Risk of Peripheral Artery Disease

Monica L. Bertoia et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Review Endocrinology & Metabolism

Lipoprotein(a) metabolism: Potential sites for therapeutic targets

Jane Hoover-Plow et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2013)

Article Biotechnology & Applied Microbiology

Lipoprotein(a) Serum Levels in Diabetic Patients with Retinopathy

Giulia Malaguarnera et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Biotechnology & Applied Microbiology

Lipoprotein(a) in Cardiovascular Diseases

Michele Malaguarnera et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Biochemistry & Molecular Biology

Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia

Kiyohito Arai et al.

JOURNAL OF LIPID RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

Oxidized Phospholipids Are Present on Plasminogen, Affect Fibrinolysis, and Increase Following Acute Myocardial Infarction

Gregor Leibundgut et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Article Cardiac & Cardiovascular Systems

Oxidation-Specific Biomarkers, Prospective 15-Year Cardiovascular and Stroke Outcomes, and Net Reclassification of Cardiovascular Events

Sotirios Tsimikas et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Review Biochemistry & Molecular Biology

Generation and Biological Activities of Oxidized Phospholipids

Valery N. Bochkov et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Review Medicine, General & Internal

A catalogue of reporting guidelines for health research

I. Simera et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Cardiac & Cardiovascular Systems

Oxidation-Specific Biomarkers, Lipoprotein(a), and Risk of Fatal and Nonfatal Coronary Events

Sotirios Tsimikas et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

Review Biochemistry & Molecular Biology

The role of lipoprotein-associated phospholipase A(2) in atherosclerosis may depend on its lipoprotein carrier in plasma

Constantinos C. Tellis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

Article Biochemistry & Molecular Biology

The role of oxidized phospholipids in atherosclerosis

Judith A. Berliner et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Cardiac & Cardiovascular Systems

Longitudinal cohort study on the effectiveness of lipid apheresis treatment to reduce high lipoprotein(a) levels and prevent major adverse coronary events

Beate R. Jaeger et al.

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2009)

Article Cardiac & Cardiovascular Systems

In vivo markers of oxidative stress and therapeutic interventions

Sotirlos Tsimikas

AMERICAN JOURNAL OF CARDIOLOGY (2008)

Review Biochemistry & Molecular Biology

The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity

Sotirios Tsimikas et al.

CURRENT OPINION IN LIPIDOLOGY (2008)

Article Biochemistry & Molecular Biology

A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma

Claes Bergmark et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Medicine, General & Internal

Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease

S Tsimikas et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Cardiac & Cardiovascular Systems

Reduced PAF-acetylhydrolase activity associated with Lp(a) in patients with coronary artery disease

LD Tsironis et al.

ATHEROSCLEROSIS (2004)

Article Cardiac & Cardiovascular Systems

Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes

S Tsimikas et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2003)