Journal
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
Volume 61, Issue 2, Pages 388-392Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ejcts/ezab435
Keywords
Ascending aortic aneurysm; Diabetes mellitus; Metformin
Funding
- Swedish Research Council [12660]
- Swedish Heart-Lung Foundation [20180451]
- Stockholm County Council [20180072]
- Swedish Heart-Lung Foundation [20180451] Funding Source: Swedish Heart-Lung Foundation
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This study found no association between Metformin treatment and prevalence of AscAA, but revealed an inverse association between diabetes and AscAA prevalence.
OBJECTIVES Metformin therapy has previously been associated with reduced abdominal aortic aneurysm growth rate in diabetic patients and shown to suppress the formation and progression of abdominal aortic aneurysm in normoglycemic mice. Here, we investigated the association between Metformin treatment and prevalence of aneurysm in the ascending aorta (AscAA). METHODS A total of 734 patients undergoing open-heart surgery for AscAA and/or aortic valve disease were studied. Diabetes status and medication use were self-reported by the patients in a systematic questionnaire. Aortic dilatation was defined as an aortic root or ascending aortic diameter >= 4.0 cm. High-sensitivity C-reactive protein levels were assessed as a measure of systemic inflammation. RESULTS We could confirm the inverse association between diabetes and AscAA prevalence (16% vs 43.9%, for diabetic and non-diabetic patients, respectively; Odds ratio 0.243; 95% CI, 0.129-0.460, P < 0.001). Furthermore, in diabetic patients, Metformin treatment was associated with lower high-sensitivity C-reactive protein levels. There was, however, no difference in the prevalence of AscAA among diabetic patients with and without Metformin treatment (16% vs 16% for treated and non-treated patients, respectively; OR 1.039; 95% CI 0.26-4.19, P = 0.957). CONCLUSIONS Our data do not support a protective effect of Metformin therapy in AscAA formation.
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