Effect of ambient air pollutants on in vitro fertilization-embryo transfer pregnancy outcome in Zhengzhou, China

With the acceleration of China's urbanization and industrialization, air pollution has become a major environmental problem. Retrospective data analysis of 6564 patients who underwent IVF-ET in the center for reproductive medicine of the First Affiliated Hospital of Zhengzhou University from 2015 to 2020. Different stages were selected from 90 days before oocyte retrieval to 35 days after transfer and divided into five exposure periods. Multivariate logistic regression was used to analyze the relationship between six ambient air pollutants (PM2.5, PM10, NO2, SO2, CO and O-3) and the IVF-ET pregnancy outcome. The results showed that air pollutants can significantly affect the IVF pregnancy outcome. The harmful effects of ambient air pollutants are more obvious in the patients aged < 35 years, single embryo transfer and cleavage stage embryo transfer.

Automated summary

With the rapid urbanization and industrialization in China, air pollution has become a significant environmental issue. A retrospective data analysis of 6564 patients from the Center for Reproductive Medicine at the First Affiliated Hospital of Zhengzhou University between 2015 and 2020 revealed that air pollutants have a significant impact on the outcome of in vitro fertilization and embryo transfer (IVF-ET), particularly in patients younger than 35 years old, those undergoing single embryo transfer, and cleavage stage embryo transfer.