Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 87, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.etap.2021.103726
Keywords
DEHP; ILC2; Innate immune system; Allergy
Funding
- Japan Society for the Promotion of Science (JSPS) [JP16H06308]
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DEHP, a plasticizer, exacerbates allergic diseases by affecting the response of group 2 innate lymphoid cells (ILC2), which produce Th2 cytokines. This study provides the first evidence that DEHP worsens allergies through the innate immune system.
Epidemiological and experimental studies have shown that di-(2-ethylhexyl) phthalate (DEHP), a plasticizer, can aggravate allergic diseases. DEHP promotes adaptive immune responses, although its effect on the innate immune system remains largely unknown. The present study investigated the effects of DEHP on group 2 innate lymphoid cells (ILC2) that produce Th2 cytokines in response to epithelial cell-derived cytokines, such as interleukin (IL)-33. ILC2 (lineage-negative, CD45.2(+), Sca1(+), KLRG1(+)) were isolated from the lungs of C57BL/6 J mice. Co-exposure to DEHP and IL-33 significantly increased IL-5 release from ILC2, whose level was higher than that of the vehicle and IL-33 alone. The effects of DEHP in the presence of IL-33 showed an inverted-U dose-response. The present is the first report showing that DEHP exacerbates allergy through the innate immune system.
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