Journal
ENVIRONMENTAL RESEARCH
Volume 203, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2021.111902
Keywords
Pesticides; Autism spectrum disorder; Glyphosate; Chlorpyrifos; Pyrethroids; Avermectins
Funding
- Doctoral Start-up Foundation of Guizhou Medical University [J [2020] 36, J [2020] 37]
- Guizhou Medical University Training Program for National Natural Science Foundation of China [20NSP059, 20NSP060]
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Agricultural pesticides have significant impacts on nervous system development, particularly during pregnancy and lactation. Recent studies have found a close relationship between low-level pesticide exposure and autism spectrum disorder (ASD), with inhibition of acetylcholinesterase being a key factor in pesticide effects on nervous system development.
Agricultural pesticides have been one of the most extensively used compounds throughout the world. The main sources of contamination for humans are dietary intake and occupational exposure. The impairments caused by agricultural pesticide exposure have been a significant global public health problem. Recent studies have shown that low-level agricultural pesticide exposure during the critical period of neurodevelopment (pregnancy and lactation) is closely related to autism spectrum disorder (ASD). Inhibition of acetylcholinesterase, gut microbiota, neural dendrite morphology, synaptic function, and glial cells are targets for the effects of pesticides during nervous system development. In the present review, we summarize the associations between several highly used and frequently studied pesticides (e.g., glyphosate, chlorpyrifos, pyrethroids, and avermectins) and ASD. We also discusse future epidemiological and toxicological research directions on the relationship between pesticides and ASD.
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