Journal
ENVIRONMENTAL POLLUTION
Volume 286, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2021.117296
Keywords
Bisphenol A; Mouth Neoplasms; Cell Culture techniques; Histone acetylation; Estrogen
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil [406548/2018-8]
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BPA poses harmful effects on oral mucosa and both tumorigenic and non-tumorigenic cells, leading to increased proliferative activity in oral tissues, disruption of keratinocytes function, and induction of proliferative, invasive, pro-angiogenic, and epigenetic pathways in tumor cells.
Bisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. The major route of BPA contamination being oral, the aim of the present study was to investigate BPA effects on oral cells. Here, we evaluated the impact of sub-chronic in vivo exposure to BPA and its in vitro effects on neoplastic and non-neoplastic oral cells. We evaluated the oral mucosa of mice chronically exposed to BPA (200 mg/L). The response of keratinocytes (NOK-SI) and Head and Neck (HN) Squamous Cell Carcinoma (SCC), HN12 and HN13 cell lines to BPA was examined. In vivo, BPA accumulated in oral tissues and caused an increase in epithelial proliferative activity. BPA disrupted the function of keratinocytes by altering pro-survival and proliferative pathways and the secretion of cytokines and growth factors. In tumor cells, BPA induced proliferative, invasive, pro-angiogenic, and epigenetic paths. Our data highlight the harmful effects of BPA on oral mucosa and, tumorigenic and non-tumorigenic cells. Additionally, BPA may be a modifier of oral cancer cell behavior by prompting a functional shift to a more aggressive phenotype.
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