Journal
ENVIRONMENT INTERNATIONAL
Volume 156, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2021.106704
Keywords
Biomarkers of effect; Firemen; Fire emissions; Occupational exposure; Health risks
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT) [UIDB/50006/2020, UIDP/50006/2020, PCIF/SSO/0090/2019]
- Ministerio da Ciencia, Tecnologia e Ensino Superior (MCTES)
- CEECIndividual 2017 Program [CEECIND/03666/2017, 2020.07394]
- Fundação para a Ciência e a Tecnologia [PCIF/SSO/0090/2019] Funding Source: FCT
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Firefighting is physically and physiologically exhausting with exposure to toxic fire emissions. Biomonitoring studies have significantly contributed to characterizing occupational-related health effects in firefighters, calling for further research to gain a deeper understanding of the health risks and to improve surveillance programs.
Firefighting is physically and physiologically exhausting besides encompassing exposure to toxic fire emissions. Biomonitoring studies from the past five years have been significantly contributing to characterize the occupational-related health effects in this group of professionals and to improve risk assessment. Therefore, this study gathers and critically discusses the most characterized biomarkers of effect (oxidative stress, DNA and protein damage, stress hormones, inflammation, and vascular, lung, and liver injury), including those potentially more promising to be explored in future studies, and their relation with health outcomes. Various studies proved an association between exposures to fire emissions and/or heat and significantly altered values of biomarkers of inflammation (soluble adhesion molecules, tumor necrosis factor, interleukins, and leucocyte count), vascular damage and tissue injury (pentraxin-3, vascular endothelial growth factor, and cardiac troponin T) in firefighting forces. Moreover, preliminary data of DNA damage in blood, urinary mutagenicity and 8-isoprostaglandin in exhaled breath condensate suggest that these biomarkers of oxidative stress should be further explored. However, most of the reported studies are based on cross-sectional designs, which limit full identification and characterization of the risk factors and their association with development of work-related diseases. Broader studies based on longitudinal designs and strongly supported by the analysis of several types of biomarkers in different biological fluids are further required to gain deeper insights into the firefighters occupational related health hazards and contribute to implementation of new or improved surveillance programs.
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