MOS is a novel genetic marker for human early embryonic arrest and fragmentation

Review Obstetrics & Gynecology

Environment, Lifestyle, and Female Infertility

Renu Bala et al.

Summary: Lifestyle and environmental factors have a significant impact on women's fertility, particularly with modern lifestyle choices and delayed childbearing age providing more opportunities for these factors to affect fertility. These factors mainly act through neuroendocrine pathways, leading to metabolic disturbances.

REPRODUCTIVE SCIENCES (2021)

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Article Medicine, Research & Experimental

Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation

Yin-Li Zhang et al.

Summary: Rare MOS variants were identified in infertile females with EEAF, leading to decreased ERK phosphorylation and disruption of maternal mRNA clearance related to mitochondrial function. Inactivation of the MOS-ERK signaling pathway drives EEAF by impairing oocyte cytoplasmic maturation in humans as shown in mice models.

EMBO MOLECULAR MEDICINE (2021)

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Review Genetics & Heredity

Genetic factors as potential molecular markers of human oocyte and embryo quality

Qing Sang et al.

Summary: This review outlines the genetic determinants of abnormalities in human oocyte maturation, fertilization, and early embryonic development, identifying 16 genes that may cause oocyte maturation arrest, fertilization failure, and embryonic lethality. These genetic markers lay the foundation for individualized genetic counseling and potential treatments in reproductive medicine.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Cell Biology