4.8 Article

Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Sclerostin-Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters

Mariah Farrell et al.

Summary: Obesity is a risk factor for many cancers and can increase bone marrow adipose tissue (BMAT), which may contribute to cancer progression. Activation of PPAR-γ can lead to increased BMAT, while the use of Scl-Ab has been shown to reverse the effects and improve bone parameters in an animal model.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

Article Cell & Tissue Engineering

Tracing the skeletal progenitor transition during postnatal bone formation

Hui Sophie Shu et al.

Summary: Different types of skeletal progenitors contribute to endochondral bone development, with postnatal osteoblasts primarily arising from chondrocytes before adolescence and Lepr(+) BMSCs after adolescence. Transition occurs in the diaphysis during adolescence and spreads to the metaphysis, with fetal Col2(+) cells giving rise to Lepr(+) BMSCs. Conditional deletion of Runx2 affects bone lengthening and thickening, and forced running promotes osteoblast formation from chondrocytes but not BMSCs. Short-term developmental skeletal progenitors generate long-term adult skeletal progenitors, regulating the growth and maintenance of endochondral bones.

CELL STEM CELL (2021)

Article Cell Biology

Regional specialization and fate specification of bone stromal cells in skeletal development

Kishor K. Sivaraj et al.

Summary: Bone stroma plays a crucial role in regulating osteogenesis and hematopoiesis, as well as fracture healing and disease processes. BMSCs from different bone regions, such as metaphysis and diaphysis, exhibit distinct characteristics and functions. The fate of BMSCs is controlled by signaling pathways involving PDGFR beta and transcription factor Jun-B, contributing to bone development and our understanding of BMSC lineage relationships and differentiation.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Yuki Matsushita et al.

NATURE COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

Generalizing RNA velocity to transient cell states through dynamical modeling

Volker Bergen et al.

NATURE BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

Christian H. Holland et al.

GENOME BIOLOGY (2020)

Article Biochemistry & Molecular Biology

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia

Ninib Baryawno et al.

Article Multidisciplinary Sciences

The bone marrow microenvironment at single-cell resolution

Anastasia N. Tikhonova et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

A cellular census of human lungs identifies novel cell states in health and in asthma

Felipe A. Vieira Braga et al.

NATURE MEDICINE (2019)

Article Cell & Tissue Engineering

Identification of Functionally Distinct Mx1+αSMA plus Periosteal Skeletal Stem Cells

Laura C. Ortinau et al.

CELL STEM CELL (2019)

Article Biotechnology & Applied Microbiology

Dimensionality reduction for visualizing single-cell data using UMAP

Etienne Becht et al.

NATURE BIOTECHNOLOGY (2019)

Article Biotechnology & Applied Microbiology

Cytoscape Automation: empowering workflow-based network analysis

David Otasek et al.

GENOME BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Mapping the Mouse Cell Atlas by Microwell-Seq

Xiaoping Han et al.

Article Cell Biology

Stem cell niche-specific Ebf3 maintains the bone marrow cavity

Masanari Seike et al.

GENES & DEVELOPMENT (2018)

Article Multidisciplinary Sciences

Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin

Oriane Duchamp de lageneste et al.

NATURE COMMUNICATIONS (2018)

Article Immunology

The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair

Danka Grcevic et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Discovery of a periosteal stem cell mediating intramembranous bone formation

Shawon Debnath et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

SCANPY: large-scale single-cell gene expression data analysis

F. Alexander Wolf et al.

GENOME BIOLOGY (2018)

Article Biochemical Research Methods

SCENIC: single-cell regulatory network inference and clustering

Sara Aibar et al.

NATURE METHODS (2017)

Letter Biochemical Research Methods

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

Susanne C. van den Brink et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu et al.

NATURE METHODS (2017)

Review Endocrinology & Metabolism

Bone marrow adipocytes

Mark C. Horowitz et al.

ADIPOCYTE (2017)

Review Immunology

Adult haematopoietic stem cell niches

Genevieve M. Crane et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Tracing haematopoietic stem cell formation at single-cell resolution

Fan Zhou et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

Daniel L. Worthley et al.

Article Biochemistry & Molecular Biology

Identification and Specification of the Mouse Skeletal Stem Cell

Charles K. F. Chan et al.

Article Biochemistry & Molecular Biology

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko et al.

Article Biotechnology & Applied Microbiology

Spatial reconstruction of single-cell gene expression data

Rahul Satija et al.

NATURE BIOTECHNOLOGY (2015)

Article Biochemistry & Molecular Biology

i-cisTarget 2015 update: generalized cis-regulatory enrichment analysis in human, mouse and fly

Hana Imrichova et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemical Research Methods

HTSeq-a Python framework to work with high-throughput sequencing data

Simon Anders et al.

BIOINFORMATICS (2015)

Article Biochemical Research Methods

jvenn: an interactive Venn diagram viewer

Philippe Bardou et al.

BMC BIOINFORMATICS (2014)

Article Multidisciplinary Sciences

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Saravana K. Ramasamy et al.

NATURE (2014)

Article Multidisciplinary Sciences

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

Liu Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Multidisciplinary Sciences

Arteriolar niches maintain haematopoietic stem cell quiescence

Yuya Kunisaki et al.

NATURE (2013)

Article Multidisciplinary Sciences

Endothelial and perivascular cells maintain haematopoietic stem cells

Lei Ding et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Endocrinology & Metabolism

Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage

Jesus Delgado-Calle et al.

Article Biochemistry & Molecular Biology

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

Satoshi Yamazaki et al.

Article Biochemistry & Molecular Biology

Molecular Silencing of Twist1 Enhances Osteogenic Differentiation of Murine Mesenchymal Stem Cells: Implication of FGFR2 Signaling

Hichem Miraoui et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2010)

Article Multidisciplinary Sciences

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Simon Mendez-Ferrer et al.

NATURE (2010)

Article Endocrinology & Metabolism

Strain-Specific Effects of Rosiglitazone on Bone Mass, Body Composition, and Serum Insulin-Like Growth Factor-I

Cheryl L. Ackert-Bicknell et al.

ENDOCRINOLOGY (2009)

Article Multidisciplinary Sciences

Endochondral ossification is required for haematopoietic stem-cell niche formation

Charles K. F. Chan et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Identification of White Adipocyte Progenitor Cells In Vivo

Matthew S. Rodeheffer et al.

Article Biochemistry & Molecular Biology

Dimorphic effects of Notch signaling in bone homeostasis

Feyza Engin et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

Matthew J. Hilton et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

Benedetto Sacchetti et al.

Article Biochemistry & Molecular Biology

Neuroepithelial cells supply an initial transient wave of MSC differentiation

Yasuhiro Takashima et al.

Article Cell Biology

MEF2C transcription factor controls chondrocyte hypertrophy and bone development

Michael A. Arnold et al.

DEVELOPMENTAL CELL (2007)

Article Cell & Tissue Engineering

Two distinct stem cell lineages in murine bone marrow

Yoko Koide et al.

STEM CELLS (2007)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Tenomodulin is necessary for tenocyte proliferation and tendon maturation

D Docheva et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus

J DeFalco et al.

SCIENCE (2001)