Cobalt-decorated 3D hybrid nanozyme: A catalytic amplification platform with intrinsic oxidase-like activity

Research about constructing multi-dimensional carbon nanomaterials is of great significance in electrocatalytic and sensing fields in order to integrate structural merits of each individual unit. Also, nano-materials with enzyme-like activities are prospective candidates for artificial enzyme design and electrochemical application. Herein, we fabricate Co, N co-doped hierarchical hybrid (Co@NCNTs/NC) nanozyme, which integrates of both N-doped carbon nanotubes (NCNTs) and N-doped carbon sheets (NC). The three-dimensional (3D) porous carbon composite is prepared by thermal treatment of metal-organic framework (MOF) which was synthesized by growing of ZIF-67 on ZIF-L at room temperature. The obtained nanomaterial not only possesses an improved oxidase-like activity that can catalyze 3,3',5,5'-tetramethylbenzidine (TMB) in the absence of hydrogen peroxide (H2O2), but also constructs a signal amplification platform towards dopamine (DA) due to the synergistic catalysis of Co species and N-doped porous carbon architecture. The electrocatalytic performance for DA detection shows a broad linear range from 30 nM to 710 mu M and a detection limit of 9 nM. The Co@NCNTs/NC/GCE is employed to practically detect DA in human serum and artificial cerebrospinal fluid (aCSF) samples with satisfactory results. The present work exhibits a great promising in colorimetric and electrochemical sensing fields and presents a new sight for the fabrication of MOF-derived nanozyme. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

In this study, a hierarchical hybrid nanozyme with Co and N co-doping was fabricated, showing excellent oxidase-like activity and signal amplification platform for dopamine detection. The three-dimensional porous carbon composite prepared by thermal treatment of MOF exhibited promising results in detecting dopamine in practical samples.