Selective Determination of Nicorandil with a Single Planar Solid-state Potentiometric Ion Selective Electrode

Novel screen-printed electrodes (SPEs) were constructed for the quantitation of nicorandil (NIC) in its pharmaceutical formulations. Different ion-exchangers and plasticizers were investigated, but the optimal potentiometric response was obtained using nicorandil-phosphotungstate (NIC-PTA) ion associate and tricresyl phosphate as a plasticizer. A Nernstian response of 58.80 +/- 1 mV/decade was obtained over a concentration range of (1x10(-6)-1x10(-2)) M with 1x10(-5) M as a detection limit. Sensor morphology was characterized using scanning electron microscopy (SEM). The method was validated for the assay of NIC with high selectivity, accuracy (average recovery=100.54 %), and precision (%RSD <= 2).

Automated summary

In this study, novel screen-printed electrodes were developed for quantifying the amount of nicorandil in pharmaceutical formulations. The optimal potentiometric response was achieved by using nicorandil-phosphotungstate ion associate and tricresyl phosphate as a plasticizer. The developed method showed high selectivity, accuracy, and precision for the assay of nicorandil.