Journal
EJSO
Volume 48, Issue 7, Pages 1498-1502Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejso.2022.02.021
Keywords
Breast cancer; Breast conserving surgery; Free margins; Re-excision rate; Margin probe
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This study evaluated the application of Margin Probe in patients undergoing lumpectomy for breast cancer and found that it has a relatively low sensitivity in detecting positive margins and a high false-positive rate, resulting in unnecessary margin shavings.
Introduction: Up to 30% of patients undergoing lumpectomy for breast cancer are in need for re-excision due to either close or involved margins. We evaluated the yield of Margin Probe (c) (MP; Dilon Technologies, USA) in a cohort of patients undergoing lumpectomy for both palpable and non-palpable tumors. Methods: Following lumpectomy, margins were evaluated with MP and readings were compared to the lumpectomies' pathological evaluation irrespective of whether additional margins were removed during surgery. Involved margins or the presence of DCIS within 1 mm of the resection margins were considered as positive margins. Results: 48 patients with 51 tumors underwent lumpectomy. Thirteen of the 51 lumpectomies had pathological close or involved margins. MP identified 3 out of the 13 positive margins. False-positive readings were recorded in 97 out of 287 margins. The sensitivity, specificity, positive predictive value and negative predictive value were 23.1% (95%CI 5.0% 53.8%), 66.4% (95%CI 60.7%-71.9%), 3% (95%CI 0.6% -8.5%), and 95.1% (95%CI 91.1%-97.6%) respectively. Conclusions: MP cancer detection rate is relatively low while high false-positive rate leads to unnecessary shavings in almost all patients. Evaluation of MP performance should be based on comparing MP read to pathology report. (c) 2022 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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