Improving screening model of pesticide risk assessment in surface soils: Considering degradation metabolites

As pesticides can be degraded to toxic metabolites in the soil, metabolite toxicity should be considered in human health risk assessments. In this study, a screening-level modeling framework was developed to manage pesticides in surface soil, which was discussed under discrete and continuous emission scenarios. In addition, we selected glyphosate and its major metabolite (aminomethylphosphonic acid or AMPA) as examples to conduct screeninglevel risk management at regional, national, and global scales. The results indicated that if soil AMPA were not considered, human health risks could be significantly underestimated because of the large half-life of AMPA in the soil. For example, the added concentration factors of AMPA were simulated as 0.19 and 6.72 considering all major elimination pathways and considering the degradation pathway alone, respectively, indicating that AMPA formation could lead to severe extra health burdens. Furthermore, the evaluation of current glyphosate soil standards suggested that toxic metabolites should be considered in the regulatory process; otherwise, many standards could theoretically trigger high levels of soil AMPA, which could result in serious human health damage. Our proposed screening-level model can help to improve risk assessment and regulatory management of pesticides in surface soils.

Automated summary

The study highlighted the importance of considering toxic metabolites, such as AMPA, in pesticide risk assessments in surface soils. Failure to account for AMPA in soil could lead to significant underestimation of human health risks. The proposed screening-level model can aid in improving risk assessment and regulatory management practices for pesticides.