Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 228, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2021.112992
Keywords
Melamine cyanuric acid; Thyroid; Circadian rhythm; UCP1
Categories
Funding
- Key Program of the National Natural Science Foundation of China [61633012]
- National Key R&D Program of China [2019YFB1309704]
- Special Fund for Basic Research on Scientific Instruments of the Chinese National Natural Science Foundation [62027812]
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Exposure to MCA may disrupt circadian rhythm and thyroid function in adult mice, affecting wheel-running and rest time, hormone homeostasis, gene expression, and thyroid histological morphology.
MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, the effects on the circadian rhythm and thyroid in adult mice have not been studied. In this article, adult male mice received MCA at concentrations of 0, 10, 20, 30 mg/kg. The results showed that the time spending on wheel-running and rest bouts changed in different period after MCA exposure. MCA disrupted the T3 and T4 hormone homeostasis and decreased the expression of thyroid hormone synthesis genes. The histological morphology of the thyroid gland was damaged. It was suggested that MCA exposure caused circadian rhythm disorder and thyroid dysfunction.
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