4.7 Article

Molecular phosphonic acid-tethered tetraphenylethene AIEgen based highly selective fluorescent turn-on sensor for neomycin

Journal

DYES AND PIGMENTS
Volume 198, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.110042

Keywords

Aminoglycoside antibiotics; AIE; Sensors; Neomycin; Colorimetric

Funding

  1. BRNS [58/14/01/2020-BRNS/37047]
  2. CSIR, New Delhi
  3. UGC-FRP
  4. Council of Scientific & Industrial Research (CSIR) , New Delhi, India [02 (0357) /19/EMR-II]
  5. CSIR-IICT [IICT/Pubs./2020/366]

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This study demonstrated the highly selective and sensitive detection of aminoglycoside antibiotic neomycin using tetraphenylethene-tetraphosphonic acids for the first time. The detection mechanism relies on electrostatic and hydrogen bonding interactions, with a detection limit of 2.088 x 10-10 M. The TPPE-based sensor system can be used for visual detection of neomycin as thin layer chromatography (TLC) sensor for real world applications.
We demonstrated highly selective and sensitive tetraphenylethene -tetraphosphonic acids for the facile detection of aminoglycoside antibiotic neomycin for the first time. Neomycin was found to effectively induce aggregate formation of (4-(1,2,2-tris(4-phosphonophenyl)vinyl)phenyl)phosphonic acid octasodium salt (TPPE) in aqueous solution. The aggregation-induced emission (AIE) response of TPPE was realized upon addition of neomycin in Milli-Q water at pH 7. The detection mechanism relies on electrostatic and hydrogen bonding interactions. The TPPE-based sensor system exhibited a detection limit 2.088 x 10-10 M of neomycin. Further, we demonstrate use of TPPE system for visual detection of neomycin as thin layer chromatography (TLC) sensor to develop kits for real world applications.

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