Journal
DYES AND PIGMENTS
Volume 195, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109677
Keywords
NIR dyes; PEGylation; Porphyrins; Bacteriochlorins; Phthalocyanines; Photophysics
Funding
- FCT - Foundation for Science and Technology, I.P. [UIDB/00313/2020, PTDC/QUI-OUT/27996/2017, PD/BD/128318/2017]
- FEDER -European Regional Development Fund through the COMPETE Programme (Operational Programme for Competitiveness)
- National Funds through FCT - Fundacao para a Ciencia e a Tecnologia (Portuguese Foundation for Science and Technology) [REEQ/481/QUI/2006, RECI/QEQ-QFI/0168/2012, CENTRO-07-CT62-FEDER002012]
- Rede Nacional de Ressonancia Magnetica Nuclear (RNRMN)
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-OUT/27996/2017, PD/BD/128318/2017] Funding Source: FCT
Ask authors/readers for more resources
The design and synthesis of new near infrared (NIR) biocompatible dyes have garnered significant interest in recent years. This study reports the synthesis of two new water soluble NIR dyes with favorable photostability and potential for applications in photodynamic therapy and optical imaging.
The design and synthesis of new near infrared (NIR) biocompatible dyes have been of great interest over the last years. Herein, the synthesis of two new water soluble NIR dyes is reported: a PEGylated (PEG = polyethyleneglycol) fluorinated bacteriochlorin [5,10,15,20-tetrakis(4-PEG(500)-2,3,5,6-fluorophenyl)bacterio-chlorin], prepared in a straightforward synthetic strategy involving a solventless reduction; and an improved strategy to prepare a PEGylated tetra-substituted free-base phthalocyanine [2(3),9(10),16(17),23(24)-tetrakis(4-PEG(200))phthalocyanine], obtained in 52% overall yield, from the PEGylated phthalonitrile. Photophysical characterization and photostability studies were performed, where both dyes showed favorable photostability and the PEGylated fluorinated bacteriochlorin presented good singlet oxygen quantum yield, showing potential to use as a photosensitizer for PDT (photodynamic therapy). Additionally, the free-base PEGylated phthalocyanine displayed reasonably high Stokes shift, suggesting high potential to use in optical imaging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available