Journal
DYES AND PIGMENTS
Volume 198, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.110026
Keywords
Aza-BODIPY; Vinyl substitution; Near-infrared; Dye nanoparticles; Photothermal conversion
Funding
- National Natural Science Foundation of China [22078201, U1908202]
- Chunhui Program cooperative research project of Education Ministry, Natural Science Foundation of Liaoning [2021NLTS1206]
- Liaoning BaiQianWan Talents Program
- serving local project of Education Department of Liaoning Province [LZ2020005]
- Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment [2021JH13/10200018, 21-104-0-23]
- Distinguished Professor Project Liaoning Province [20183532]
Ask authors/readers for more resources
A novel vinyl-containing pyrrole compound was developed through the reaction of vinyl-containing ketones with 3-phenyl-2H-azirine in the presence of LDA. This compound was then used to prepare asymmetric vinyl-containing azaBDPs 1-8, avoiding the use of Knoevenagel condensation. Among them, the formed azaBDP nanoparticles (7-NPs) exhibited excellent photothermal stabilities and a high photothermal conversion efficiency (eta = 55%) in the aza-BODIPY system, effectively killing cancer cells through photothermal conversion, showing potential as a tumor phototherapeutic agent.
Novel vinyl-containing pyrroles were developed by the reaction of vinyl-containing ketones with 3-phenyl-2H-azirine in the presence of LDA. Utilizing these pyrroles, asymmetric vinyl-containing azaBDPs 1-8 were prepared, avoiding to the use of Knoevenagel condensation. Solid-state structure of 7 was confirmed by X-ray crystallographic analysis, and the furan, the vinyl group and the pyrrole segment in 7 are almost coplanar, owing to the conjugation. AzaBDPs 1-8 absorb and emit beyond 685 nm, and have low fluorescence quantum yields. AzaBDPs 1-8 were found to merely possess the O-1(2) production capacity. The formed azaBDP nanoparticles (7-NPs) by facile encapsulation of F127 exhibit the excellent photothermal stabilities. Noteworthily, 7-NPs show the outstanding photothermal conversion efficiency (eta = 55%) in aza-BODIPY system, and can effectively kill cancer cells through the photothermal conversion, which is highly desirable for an effective and potential tumor phototherapeutic reagent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available