Journal
DYES AND PIGMENTS
Volume 194, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2021.109586
Keywords
Near-infrared probe; Fluorescence imaging; Photoacoustic imaging; Drug-induced liver injury
Funding
- National Natural Science Foundation of China [21877080, 91959105]
- Shanghai Engineering Research Center of Green Energy Chemical Engineering [18DZ2254200]
- International Joint Laboratory on Resource Chemistry (IJLRC)
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Cy-ZnDPA is a targeted probe that can accurately diagnose DILI and locate the lesion area, with potential applications in other apoptotic-related physiological and pathological processes.
Drug-induced liver injury (DILI) arising from chemicals or therapeutic drugs is mainly responsible for liver diseases, which makes the early diagnosis of DILI particularly important. Herein, we developed a targeted probe of zinc-bis(dipicolylamine) conjugated cyanine dye (Cy7-ZnDPA), in which ZnDPA would target phosphatidylserine (PS) on the surface of apoptotic cells of DILI. Moreover, Cy-ZnDPA could overcome the tissue penetration depth and precisely locate the lesion area by means of high-resolution fluorescence and photoacoustic imaging in the DILI mice model. Cy-ZnDPA is expected to be a powerful probe for the diagnosis of other apoptotic related physiological and pathological processes.
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