Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 5, Pages 1261-1283Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2022.01.004
Keywords
Alzheimer's disease; Immune system; Immunotherapy; Innate immune system; Adaptive immune system
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The ultimate cause of Alzheimer's disease (AD) is still unknown, but the immune system plays a key role in its pathogenesis. Immunotherapy holds promise as a novel therapy for treating AD, but further research is needed to understand the interaction between AD and the different parts of our immune system.
The ultimate cause of Alzheimer's disease (AD) is still unknown and no disease-modifying treatment exists. Emerging evidence supports the concept that the immune system has a key role in AD pathogenesis. This awareness leads to the idea that specific parts of the immune system must be engaged to ward off the disease. Immunotherapy has dramatically improved the management of several previously untreatable cancers and could hold similar promise as a novel therapy for treating AD. However, before potent immunotherapies can be rationally designed as treatment against AD, we need to fully understand the dynamic interplay between AD and the different parts of our immune system. Accordingly, here we review the most important aspects of both the innate and adaptive immune system in relation to AD pathology.
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