4.7 Review

Targeting Ca2+ signaling: A new arsenal against cancer

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Thapsigargin-From Traditional Medicine to Anticancer Drug

Agata Jaskulska et al.

Summary: Thapsigargin is a sesquiterpene lactone found in Mediterranean plants, traditionally used in folk medicine for treating rheumatic pain, lung diseases, and female infertility. It has been discovered to induce apoptosis by inhibiting the SERCA pump, making it a potential antineoplastic agent, but its high toxicity to normal cells hampers its development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside

Abeer Alharbi et al.

Summary: Ca2+ dyshomeostasis is closely linked to cancer metastasis biology, playing a crucial role in various processes such as cell proliferation, adhesion, motility, invasion, and the epithelial-mesenchymal transition. Calcium signaling pathways have been identified as potential biomarkers and targets for therapeutic intervention in metastatic cancer, which remains a leading cause of cancer-related deaths. The dysregulation of Ca2+ homeostasis is implicated in physiological processes related to tumor progression, and the modulation of specific upstream/downstream targets in Ca2+ signaling may offer a promising approach for treating metastatic cancers.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Targeting the purinergic pathway in breast cancer and its therapeutic applications

Julia Beatrice de Araujo et al.

Summary: The purinergic system has been found to be associated with breast cancer, with different purinergic receptors playing different roles in the proliferation and metastasis of breast cancer cells. High expression of CD39 and CD73 is strongly related to a worse prognosis. These receptors and enzymes may become therapeutic targets for breast cancer.

PURINERGIC SIGNALLING (2021)

Review Pharmacology & Pharmacy

Store-Operated Calcium Channels as Drug Target in Gastroesophageal Cancers

Yan Chang et al.

Summary: The review discusses the impact of dysregulated store-operated calcium entry (SOCE) on gastroesophageal cancers, including its role in cancer cell proliferation, migration, invasion, and stemness maintenance. Efforts towards developing more specific and potent SOCE inhibitors as a new set of chemotherapeutic drugs for targeted therapy or adjuvant treatment to overcome drug resistance in gastroesophageal cancers are also highlighted.

FRONTIERS IN PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Development of Store-Operated Calcium Entry-Targeted Compounds in Cancer

Xiaojing Liang et al.

Summary: Store-operated Ca2+ entry (SOCE) is the major pathway of Ca2+ entry in mammalian cells and has been shown to be closely related to cancer development. Developing compounds targeting SOCE is proposed as a potential and effective strategy for cancer therapy.

FRONTIERS IN PHARMACOLOGY (2021)

Review Oncology

TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer

Maria Paz Saldias et al.

Summary: Breast cancer is a leading cause of cancer-related deaths in women globally, and developing new molecular therapies to target the disease is crucial. Ion channels play a significant role in cancer progression, making them potential therapeutic targets.

FRONTIERS IN ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Calcium Permeable Channels in Cancer Hallmarks

Sendoa Tajada et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

Anindya Roy Chowdhury et al.

ISCIENCE (2020)

Review Biochemistry & Molecular Biology

Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials

Fruzsina Kiss et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Targeting the Calcium Signalling Machinery in Cancer

Jason I. E. Bruce et al.

CANCERS (2020)

Review Biochemistry & Molecular Biology

Role of Sodium/Calcium Exchangers in Tumors

Barbora Chovancova et al.

BIOMOLECULES (2020)

Review Biochemistry & Molecular Biology

Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer

Simone Patergnani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

CCL18 in the Progression of Cancer

Jan Korbecki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

T-Type voltage gated calcium channels: a target in breast cancer?

Anamika Bhargava et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

Review Medicine, Research & Experimental

Exosomes as Drug Carriers for Cancer Therapy

Jessica E. Pullan et al.

MOLECULAR PHARMACEUTICS (2019)

Article Pharmacology & Pharmacy

Mibefradil, a T-type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface

Pengyun Li et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection

Elizabeth Varghese et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Pharmacology & Pharmacy

The multi-factorial nature of clinical multidrug resistance in cancer

Yehuda G. Assaraf et al.

DRUG RESISTANCE UPDATES (2019)

Article Pharmacology & Pharmacy

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels

Sara Baratchi et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

The application of nitric oxide delivery in nanoparticle-based tumor targeting drug delivery and treatment

Lin Qin et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Review Cell & Tissue Engineering

Role of HIF1 α Regulatory Factors in Stem Cells

Hyun Jik Lee et al.

INTERNATIONAL JOURNAL OF STEM CELLS (2019)

Review Cell Biology

SERCA control of cell death and survival

Elie R. Chemaly et al.

CELL CALCIUM (2018)

Review Cell Biology

Metabolic regulation of the PMCA: Role in cell death and survival

Jason I. E. Bruce

CELL CALCIUM (2018)

Article Biochemistry & Molecular Biology

Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection

Jessy Hasna et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Biochemistry & Molecular Biology

The interplay between HIF-1 and calcium signalling in cancer

Iman Azimi

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Review Physiology

ION CHANNELS IN CANCER: ARE CANCER HALLMARKS ONCOCHANNELOPATHIES?

Natalia Prevarskaya et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Multidisciplinary Sciences

Progress and challenges towards targeted delivery of cancer therapeutics

Daniel Rosenblum et al.

NATURE COMMUNICATIONS (2018)

Review Biochemistry & Molecular Biology

A temporal examination of calcium signaling in cancer- from tumorigenesis, to immune evasion, and metastasis

MengMeng Xu et al.

CELL AND BIOSCIENCE (2018)

Review Oncology

The hypoxic tumour microenvironment

Varvara Petrova et al.

ONCOGENESIS (2018)

Article Chemistry, Multidisciplinary

Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

Jihoon Kim et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Biochemistry & Molecular Biology

Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells

Gokhan Nur et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2017)

Review Biochemistry & Molecular Biology

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling

Rafaela Bagur et al.

MOLECULAR CELL (2017)

Article Oncology

Voltage-gated calcium channels: Novel targets for cancer therapy

Nam Nhut Phan et al.

ONCOLOGY LETTERS (2017)

Review Pharmacology & Pharmacy

Targeting calcium signaling in cancer therapy

Chaochu Cui et al.

ACTA PHARMACEUTICA SINICA B (2017)

Review Oncology

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer

Elzbieta Kania et al.

FRONTIERS IN ONCOLOGY (2017)

Article Multidisciplinary Sciences

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway

Peng Zhang et al.

SCIENTIFIC REPORTS (2017)

Review Pharmacology & Pharmacy

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Behzad Mansoori et al.

ADVANCED PHARMACEUTICAL BULLETIN (2017)

Review Oncology

The calcium-cancer signalling nexus

Gregory R. Monteith et al.

NATURE REVIEWS CANCER (2017)

Article Cell Biology

TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces

Indu S. Ambudkar et al.

CELL CALCIUM (2017)

Review Chemistry, Multidisciplinary

Transient receptor potential channel C5 in cancer chemoresistance

Dong-xu He et al.

ACTA PHARMACOLOGICA SINICA (2016)

Review Oncology

SOCE and cancer: Recent progress and new perspectives

Jiansheng Xie et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

Review Biochemistry & Molecular Biology

Calcium-ATPases: Gene disorders and dysregulation in cancer

Donna Dang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Review Physiology

THE INOSITOL TRISPHOSPHATE/CALCIUM SIGNALING PATHWAY IN HEALTH AND DISEASE

Michael J. Berridge

PHYSIOLOGICAL REVIEWS (2016)

Review Biochemistry & Molecular Biology

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

Anna Raffaello et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Article Multidisciplinary Sciences

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

Anil Noronha Antony et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry

Letizia Albarran et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent

Liang Wen et al.

SCIENTIFIC REPORTS (2016)

Review Physiology

STORE-OPERATED CALCIUM CHANNELS

Murali Prakriya et al.

PHYSIOLOGICAL REVIEWS (2015)

Article Biochemistry & Molecular Biology

Inhibition of Transient Receptor Potential Channel 5 Reverses 5-Fluorouracil Resistance in Human Colorectal Cancer Cells

Teng Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Knockdown of TRPM8 Suppresses Cancer Malignancy and Enhances Epirubicin-induced Apoptosis in Human Osteosarcoma Cells

Yongzhi Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

Article Medicine, Research & Experimental

CD4+ and CD8+ T cell-dependent antiviral immunity requires STIM1 and STIM2

Patrick J. Shaw et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance

Xin Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells

Eva C. Schwarz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Multidisciplinary Sciences

Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells

Xin Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Physiology

TRP Channels

Maarten Gees et al.

COMPREHENSIVE PHYSIOLOGY (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Cell Biology

The Ca2+ Pumps of the Endoplasmic Reticulum and Golgi Apparatus

Ilse Vandecaetsbeek et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Oncology

Calcium in tumour metastasis: new roles for known actors

Natalia Prevarskaya et al.

NATURE REVIEWS CANCER (2011)

Article Biochemistry & Molecular Biology

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

Mingye Feng et al.

Review Biochemistry & Molecular Biology

Ion channels and the hallmarks of cancer

Natalia Prevarskaya et al.

TRENDS IN MOLECULAR MEDICINE (2010)

Review Biochemistry & Molecular Biology

Gene regulation by voltage-dependent calcium channels

Maud Barbado et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

Article Oncology

The role of TRPV6 in breast carcinogenesis

Katrin A. Bolanz et al.

MOLECULAR CANCER THERAPEUTICS (2008)

Review Biochemistry & Molecular Biology

Calcium signaling

David E. Clapham

Review Biochemistry & Molecular Biology

TRP channels in cancer

Natalia Prevarskaya et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

Article Pharmacology & Pharmacy

A short history of voltage-gated calcium channels

AC Dolphin

BRITISH JOURNAL OF PHARMACOLOGY (2006)

Review Biotechnology & Applied Microbiology

Targeting multidrug resistance in cancer

G Szakács et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Biochemistry & Molecular Biology

Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!

W Liedtke et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

Review Biochemistry & Molecular Biology

Calcium and apoptosis: facts and hypotheses

R Rizzuto et al.

ONCOGENE (2003)

Review Cell Biology

Transcriptional regulation by calcium, calcineurin, and NFAT

PG Hogan et al.

GENES & DEVELOPMENT (2003)

Review Cell Biology

Calcium signalling: Dynamics, homeostasis and remodelling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Review Cell Biology

The versatility and universality of calcium signalling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)