Journal
DRUG DISCOVERY TODAY
Volume 27, Issue 5, Pages 1218-1235Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.12.016
Keywords
Experimental murine model; Brainstem glioma; Diffuse intrinsic pontine glioma
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Funding
- National Natural Science Founda-tion of China [81202924, 81773909]
- Shanghai Rising-Star Program of China [13QA1403400]
- Shang-hai Talent Development Funds [201665]
- Shanghai Municipal Commission of Health and Family Planning Grant [2017YQ060]
- State Key Laboratory of Molecular Engineering of Polymers, Fudan University [SDD2017-01]
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This review outlines the evolution of murine models for brainstem glioma (BG), one of the leading causes of pediatric death by brain tumors. The advantages and limitations of these models in drug discovery are discussed.
As an intractable central nervous system (CNS) tumor, brainstem glioma (BG) is one of the leading causes of pediatric death by brain tumors. Owing to the risk of surgical resection and the little improvement in survival time after radiotherapy and chemotherapy, there is an urgent need to find reliable model systems to better understand the regional pathogenesis of the brainstem and improve treatment strategies. In this review, we outline the evolution of BG murine models, and discuss both their advantages and limitations in drug discovery.
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