Journal
DNA REPAIR
Volume 107, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2021.103210
Keywords
Chromatin; DNA damage; Double-strand break; DNA repair; Genome instability
Categories
Funding
- European Research Council
- Spanish Ministry of Economy and Competitiveness
- Junta de Andalucia
- European Union (FEDER)
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Recent studies have shown the critical role of chromatin in both the occurrence and repair of DNA damage, particularly double-strand breaks. It is considered as a guardian of genome stability, which is altered in cancer cells.
It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication.
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