Journal
DNA AND CELL BIOLOGY
Volume 40, Issue 12, Pages 1495-1502Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2021.0623
Keywords
vimentin; atherosclerosis; intermediate filament; EndMT; mechanical; nonmechanical
Funding
- National Natural Science Foundation of China [31870937, 82000421]
- Natural Science Foundation of Hunan Province [2020JJ4076]
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The cytoskeleton, mainly composed of intermediate filaments, actin, and microtubules, regulates the mechanical properties of cells. Vimentin, an intermediate filament protein, has both mechanical and nonmechanical functions in atherosclerosis progression.
The cytoskeleton is a biopolymer network composed of intermediate filaments, actin, and microtubules, which is the main mechanical structure of cells. Vimentin is an intermediate filament protein that regulates the mechanical and contractile properties of cells, thereby reflecting their mechanical properties. In recent years, the nonmechanical function of vimentin inside and outside of cells has attracted extensive attention. The content of vimentin in atherosclerotic plaques is increased, and the serum secretion of vimentin in patients with coronary heart disease is remarkably increased. In this review, the mechanistic and nonmechanistic roles of vimentin in atherosclerosis progression were summarized on the basis of current studies.
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