Related references
Note: Only part of the references are listed.Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans
Yiyi Ma et al.
ALZHEIMERS & DEMENTIA (2022)
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Fangda Leng et al.
NATURE REVIEWS NEUROLOGY (2021)
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease
Luke Whiley et al.
ALZHEIMERS RESEARCH & THERAPY (2021)
Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives
Tapan Behl et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis
Anne Stinn et al.
BIOSENSORS-BASEL (2021)
Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway
Auriel A. Willette et al.
BRAIN BEHAVIOR AND IMMUNITY (2021)
Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction
Ana Belen Lopez-Rodriguez et al.
ALZHEIMERS & DEMENTIA (2021)
A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity
Omar Taleb et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Cognitive Decline in Alzheimer's Disease Is Not Associated with APOE
Ioanna Katzourou et al.
JOURNAL OF ALZHEIMERS DISEASE (2021)
Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
Heather M. Grifka-Walk et al.
FRONTIERS IN IMMUNOLOGY (2021)
Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology
Jinbo Cheng et al.
SCIENCE ADVANCES (2021)
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
Mustafa N. Mithaiwala et al.
CELLS (2021)
CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain
Chun-Lin Mai et al.
THERANOSTICS (2021)
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model
George Zakhary et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2020)
3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr(-/-) mice
Martin Berg et al.
CARDIOVASCULAR RESEARCH (2020)
Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway
Dmitry Kondrikov et al.
EXPERIMENTAL GERONTOLOGY (2020)
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation
Giada Mondanelli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder
Masashi Sakurai et al.
SCIENTIFIC REPORTS (2020)
Kynurenine Pathway as a New Target of Cognitive Impairment Induced by Lead Toxicity During the Lactation
Daniela Ramirez Ortega et al.
SCIENTIFIC REPORTS (2020)
IDO and Kynurenine Metabolites in Peripheral and CNS Disorders
Yi-Shu Huang et al.
FRONTIERS IN IMMUNOLOGY (2020)
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD(+) Synthesis During Inflammation and Infection
John R. Moffett et al.
FRONTIERS IN IMMUNOLOGY (2020)
β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
Lea L. Friker et al.
CELL REPORTS (2020)
δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia
Yi-Meng Chen et al.
FRONTIERS IN IMMUNOLOGY (2020)
Pharmacologic Induction of Endotoxin Tolerance in Dendritic Cells by L-Kynurenine
Giorgia Manni et al.
FRONTIERS IN IMMUNOLOGY (2020)
Kynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients
Marta Gonzalez-Sanchez et al.
BIOMOLECULES (2020)
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease
Niklas Lonnemann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway
Lisha Du et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
NAD(+) homeostasis in health and disease
Elena Katsyuba et al.
NATURE METABOLISM (2020)
Age- and disease-specific changes of the kynurenine pathway in Parkinson's and Alzheimer's disease
Freek J. H. Sorgdrager et al.
JOURNAL OF NEUROCHEMISTRY (2019)
Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau
Kelly R. Jacobs et al.
NEUROBIOLOGY OF AGING (2019)
Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice
Emre Fertan et al.
FRONTIERS IN PHARMACOLOGY (2019)
Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells
Marco Gargaro et al.
FRONTIERS IN IMMUNOLOGY (2019)
Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease
Pratishtha Chatterjee et al.
JOURNAL OF NEUROINFLAMMATION (2019)
NLRP3 inflammasome activation drives tau pathology
Christina Ising et al.
NATURE (2019)
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model
Elizabeth Spangenberg et al.
NATURE COMMUNICATIONS (2019)
Systemic and central nervous system metabolic alterations in Alzheimer's disease
Vera van der Velpen et al.
ALZHEIMERS RESEARCH & THERAPY (2019)
Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue Homeodynamics
Lenka Kubicova et al.
ANTIOXIDANTS (2019)
The Role of APOE and TREM2 in Alzheimers DiseaseCurrent Understanding and Perspectives
Cody M. Wolfe et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies
Xue-Ning Shen et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction
Daniel A. Nation et al.
NATURE MEDICINE (2019)
γ-[Glu]n-Trp ameliorates anxiety/depression-like behaviors and its anti-inflammatory effect in an animal model of anxiety/depression
Xiping Zhu et al.
FOOD & FUNCTION (2019)
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
Lee Peyton et al.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2019)
MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma
Saumyendra N. Sarkar et al.
AGING AND DISEASE (2019)
A critical role of TRPM2 channel in Aβ42-induced microglial activation and generation of tumor necrosis factor-α
Sharifah Alawieyah Syed Mortadza et al.
GLIA (2018)
Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR)
Seung-Hyeon Seok et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat Striatum
Paula Pierozan et al.
MOLECULAR NEUROBIOLOGY (2018)
Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts
Juho Tynkkynen et al.
ALZHEIMERS & DEMENTIA (2018)
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack et al.
ALZHEIMERS & DEMENTIA (2018)
Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection
Wazir Abdullahi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)
Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease
Mingzhe Liu et al.
BRAIN RESEARCH (2018)
Widely targeted metabolomics of Alzheimer's disease postmortem cerebrospinal fluid based on 9-fluorenylmethyl chloroformate derivatized ultra-high performance liquid chromatography tandem mass spectrometry
Yoshio Muguruma et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)
The effect of &ITAPOE&IT and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study
Sven J. van der Lee et al.
LANCET NEUROLOGY (2018)
Aryl hydrocarbon receptor and intestinal immunity
Bruno Lamas et al.
MUCOSAL IMMUNOLOGY (2018)
Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
L. A. Ramos-Chavez et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models
Michiko Sekiya et al.
GENOME MEDICINE (2018)
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
Vijay R. Varma et al.
PLOS MEDICINE (2018)
Intraventricular infusion of quinolinic acid impairs spatial learning and memory in young rats: a novel mechanism of lead-induced neurotoxicity
Abdur Rahman et al.
JOURNAL OF NEUROINFLAMMATION (2018)
Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology
Elodie Martin et al.
AGING CELL (2017)
A Simple HPLC-MS/MS Method for Determination of Tryptophan, Kynurenine and Kynurenic Acid in Human Serum and its Potential for Monitoring Antidepressant Therapy
Li-Jun Hu et al.
JOURNAL OF ANALYTICAL TOXICOLOGY (2017)
Danger-associated molecular patterns in Alzheimer's disease
Carmen Venegas et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2017)
Kynurenine Pathway Metabolites in Alzheimer's Disease
Lasse Melvaer Giil et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Peripheral inflammatory markers in Alzheimer's disease: a systematic review and meta-analysis of 175 studies
Ka Sing P. Lai et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)
Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid
Eden Flores-Barrera et al.
JOURNAL OF NEUROSCIENCE (2017)
TREM2 in Neurodegenerative Diseases
Taylor R. Jay et al.
MOLECULAR NEURODEGENERATION (2017)
Kynurenine pathway metabolism and neuroinflammatory disease
Nady Braidy et al.
NEURAL REGENERATION RESEARCH (2017)
Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors
Francesco Fazio et al.
NEUROPHARMACOLOGY (2017)
Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex
D. M. Bortz et al.
NEUROPHARMACOLOGY (2017)
Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions
Barbara Strasser et al.
NEUROPHARMACOLOGY (2017)
3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Enhance the Toxicity Induced by Copper in Rat Astrocyte Culture
Daniela Ramirez-Ortega et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)
TREM2, Microglia, and Neurodegenerative Diseases
Felix L. Yeh et al.
TRENDS IN MOLECULAR MEDICINE (2017)
Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders
Patrycja Brzdak et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2017)
Aging Microglia-Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases
Bjoern Spittau
FRONTIERS IN AGING NEUROSCIENCE (2017)
Major Developments in the Design of Inhibitors along the Kynurenine Pathway
Kelly R. Jacobs et al.
CURRENT MEDICINAL CHEMISTRY (2017)
Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies
Girdhar Singh Deora et al.
ACS CHEMICAL NEUROSCIENCE (2017)
Metabolic network failures in Alzheimer's disease: A biochemical road map
Jon B. Toledo et al.
ALZHEIMERS & DEMENTIA (2017)
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases
Ping Song et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network
Hideyuki Takahashi et al.
ACTA NEUROPATHOLOGICA (2017)
Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models
Elizabeth E. Spangenberg et al.
BRAIN BEHAVIOR AND IMMUNITY (2017)
Sequential Activation of Microglia and Astrocyte Cytokine Expression Precedes Increased Iba-1 or GFAP Immunoreactivity Following Systemic Immune Challenge
Diana M. Norden et al.
GLIA (2016)
The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation
Johanna Prodinger et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2016)
The endocytic pathway in microglia during health, aging and Alzheimer's disease
Santiago Sole-Domenech et al.
AGEING RESEARCH REVIEWS (2016)
Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice
Nathaniel S. Woodling et al.
BRAIN (2016)
Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging
Lorraine Hamelin et al.
BRAIN (2016)
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice
Leandro Cattelan Souza et al.
BRAIN BEHAVIOR AND IMMUNITY (2016)
Tolerogenic Phenotype of IFN-γ-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop
Qingsheng Li et al.
JOURNAL OF IMMUNOLOGY (2016)
Neuroinflammation: the devil is in the details
Damon J. DiSabato et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge
Jennifer M. Parrott et al.
JOURNAL OF NEUROINFLAMMATION (2016)
Unbiased Metabolomic Investigation of Alzheimer's Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism
Giuseppe Paglia et al.
JOURNAL OF PROTEOME RESEARCH (2016)
Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites
Carlo Breda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity
Amira Latif-Hernandez et al.
SCIENTIFIC REPORTS (2016)
Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions
Linda S. Zhang et al.
GENOME MEDICINE (2016)
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation
L. Brundin et al.
TRANSLATIONAL PSYCHIATRY (2016)
Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers
Aitak Farzi et al.
BRAIN BEHAVIOR AND IMMUNITY (2015)
The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease
Erdinc Dursun et al.
JOURNAL OF NEUROIMMUNOLOGY (2015)
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans
Edwin B. Yan et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin
Elena Zenaro et al.
NATURE MEDICINE (2015)
Mitochondrial dysfunction related to cell damage induced by 3-hydroxykynurenine and 3-hydroxyanthranilic acid: Non-dependent-effect of early reactive oxygen species production
J. Reyes-Ocampo et al.
NEUROTOXICOLOGY (2015)
The role of the kynurenine pathway in suicidality in adolescent major depressive disorder
Kailyn A. L. Bradley et al.
PSYCHIATRY RESEARCH (2015)
Roles of lndole as an Interspecies and Interkingdom Signaling Molecule
Jin-Hyung Lee et al.
TRENDS IN MICROBIOLOGY (2015)
Response of host inflammasomes to viral infection
I-Yin Chen et al.
TRENDS IN MICROBIOLOGY (2015)
Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia
Francesco Fazio et al.
SCIENTIFIC REPORTS (2015)
The IDO Inhibitor Coptisine Ameliorates Cognitive Impairment in a Mouse Model of Alzheimer's Disease
Dan Yu et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Quinolinic Acid Induces Disrupts Cytoskeletal Homeostasis in Striatal Neurons. Protective Role of Astrocyte-Neuron Interaction
Paula Pierozan et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2015)
Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation
Troy D. Hubbard et al.
DRUG METABOLISM AND DISPOSITION (2015)
Apolipoprotein E in Alzheimer's Disease: An Update
Jin-Tai Yu et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 37 (2014)
The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum
Ana Laura Colin-Gonzalez et al.
BRAIN RESEARCH (2014)
L-Kynurenine/Aryl Hydrocarbon Receptor Pathway Mediates Brain Damage After Experimental Stroke
Maria I. Cuartero et al.
CIRCULATION (2014)
Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing
Charlotte Genestet et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Interferons in the Central Nervous System: A Few Instruments Play Many Tunes
Trevor Owens et al.
GLIA (2014)
Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies
Gayathri Sundaram et al.
JOURNAL OF NEUROINFLAMMATION (2014)
A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats
Ajeesh Koshy Cherian et al.
NEUROPHARMACOLOGY (2014)
Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex
Sarah Beggiato et al.
NEUROPHARMACOLOGY (2014)
Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases
Jazmin Reyes Ocampo et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)
Development of a CZE-ESI-MS assay with a sulfonated capillary for profiling picolinic acid and quinolinic acid formation in multienzyme system
Xiaochun Wang et al.
ELECTROPHORESIS (2013)
The role of TLR2/JNK/NF-κB pathway in amyloid β peptide-induced inflammatory response in mouse NG108-15 neural cells
Wei Lin et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2013)
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
Clifford R. Jack et al.
LANCET NEUROLOGY (2013)
Review: Microglia of the aged brain: primed to be activated and resistant to regulation
D. M. Norden et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2013)
Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets
Rafael Lugo-Huitron et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain
Wei Wu et al.
PLOS ONE (2013)
The Kynurenine Pathway in Stem Cell Biology
Simon P. Jones et al.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2013)
Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection
Trevor W. Stone et al.
FEBS JOURNAL (2012)
Quinolinic acid, the inescapable neurotoxin
Gilles J. Guillemin
FEBS JOURNAL (2012)
TLR2 Is a Primary Receptor for Alzheimer's Amyloid β Peptide To Trigger Neuroinflammatory Activation
Shirong Liu et al.
JOURNAL OF IMMUNOLOGY (2012)
The kynurenine pathway in neurodegenerative diseases: Mechanistic and therapeutic considerations
Lin Tan et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2012)
CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease
Karin Westin et al.
PLOS ONE (2012)
Leukocyte CCR2 Expression Is Associated with Mini-Mental State Examination Score in Older Adults
Lorna W. Harries et al.
REJUVENATION RESEARCH (2012)
Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors
F. Fazio et al.
MOLECULAR PHARMACOLOGY (2012)
The Tryptophan Metabolite 3-Hydroxyanthranilic Acid Plays Anti-Inflammatory and Neuroprotective Roles During Inflammation
Daniela Krause et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Molecular Basis for the Substrate Stereoselectivity in Tryptophan Dioxygenase
Luciana Capece et al.
BIOCHEMISTRY (2011)
Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
Daniel Zwilling et al.
CELL (2011)
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats
Nady Braidy et al.
FEBS JOURNAL (2011)
Targeting the Kynurenine Pathway-Related Alterations in Alzheimer's Disease: A Future Therapeutic Strategy
Imola Plangar et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis
Yiquan Chen et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Comparative genotoxicity of 3-hydroxyanthranilic acid and anthranilic acid in the presence of a metal cofactor Cu (II) in vitro
Gopi S. Gadupudi et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2011)
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Christiane A. Opitz et al.
NATURE (2011)
Kynurenine and its metabolites in Alzheimer's disease patients
E. Gulaj et al.
ADVANCES IN MEDICAL SCIENCES (2010)
Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats
Paula Pierozan et al.
EXPERIMENTAL NEUROLOGY (2010)
Kynurenines, neurodegeneration and Alzheimer's disease
Zsigmond Tamas Kincses et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)
The Role of Tryptophan Catabolism along the Kynurenine Pathway in Acute Ischemic Stroke
Raf Brouns et al.
NEUROCHEMICAL RESEARCH (2010)
Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior
Michelle C. Potter et al.
NEUROPSYCHOPHARMACOLOGY (2010)
On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio
L. Gail Darlington et al.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2010)
Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release
A. Zmarowski et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway
Helen J. Ball et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo
Laura Amori et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease
Ka Ka Ting et al.
JOURNAL OF NEUROINFLAMMATION (2009)
Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guerin
Jason C. O'Connor et al.
JOURNAL OF NEUROSCIENCE (2009)
The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection
Eniko Vamos et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2009)
DIVERSE ROLES OF MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF METALLOPROTEINASES IN NEUROINFLAMMATION AND CEREBRAL ISCHEMIA
E. Candelario-Jalil et al.
NEUROSCIENCE (2009)
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides
Claudia Backhaus et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2008)
Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production
Florian L. Muller et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism
Lisa Pucci et al.
FEBS JOURNAL (2007)
In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain
Guilhian Leipnitz et al.
NEUROCHEMISTRY INTERNATIONAL (2007)
Molecules in focus: Indoleamine 2,3-dioxygenase
Nicholas J. C. King et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
Jinghong Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones
S Cai et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)
Reduced ingestion of sweetened milk induced by interleukin-1 and lipopolysaccharide is associated with induction of cyclooxygenase-2 in brain endothelia
Adrian J. Dunn et al.
NEUROIMMUNOMODULATION (2006)
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus
GJ Guillemin et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2005)
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β-peptide
KP Townsend et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
Quinolinic acid induces NMDA receptor-mediated lipid peroxidation in rat brain microvessels
F St'astny et al.
REDOX REPORT (2004)
AβI-42 induces production of quinolinic acid by human macrophages and microglia
GJ Guillemin et al.
NEUROREPORT (2003)
Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes
GJ Guillemin et al.
GLIA (2003)
Electrochemical and in vitro evaluation of the redox-properties of kynurenine species
GI Giles et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Lipid peroxidation in aging brain and Alzheimer's disease
TJ Montine et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection
GJ Guillemin et al.
JOURNAL OF NEUROCHEMISTRY (2001)
3-Hydroxyanthranilic acid, an L-tryptopban metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-γ
T Morita et al.
ANNALS OF CLINICAL BIOCHEMISTRY (2001)
Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection
MP Heyes et al.
BRAIN (2001)
Quinolinic acid induces oxidative stress in rat brain synaptosomes
A Santamaría et al.
NEUROREPORT (2001)
The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1α and-1β in macrophages
MC Bosco et al.
JOURNAL OF IMMUNOLOGY (2000)
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus
HQ Wu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2000)
Inflammation and Alzheimer's disease
H Akiyama et al.
NEUROBIOLOGY OF AGING (2000)