Journal
DIGESTIVE AND LIVER DISEASE
Volume 54, Issue 7, Pages 864-870Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2022.01.002
Keywords
Locally recurrent rectal cancer; Neoadjuvant therapy; Neutrophil-to-lymphocyte ratio; Overall survival; Platelet-to-lymphocyte ratio
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This study evaluated the prognostic role of peripheral immune estimators (NLR and PLR) in survival outcomes of locally recurrent rectal cancer patients. The study found that NLR and PLR were associated with worse 5-year overall survival rate and could serve as prognostic markers. However, NLR and PLR were irrelevant in cases of R0 surgery.
Background: Prognostic features in locally recurrent rectal cancer (LRRC), beyond R0 surgery, are unknown. Aims: Aim of the present study was to evaluate the prognostic role of peripheral immune estimators, such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), on survival outcomes in LRRC patients. Methods: 184 LRRC patients treated at the National Cancer Institute of Milan (Italy) were included. Optimal cut-offvalues for NLR and PLR were determined. Kaplan-Meier curves and multivariate Cox analyses were used to assess the 5-yr overall survival (OS) according to NLR and PLR, also considering margins status. Results: NLR >3.9 (hazard ratio [HR] 3.96, P = 0.049), PLR >275 (HR 5.39, P = 0.002) and size on imaging (HR 1.36, P = 0.044) were associated to worse OS. R+ patients with NLR >3.9 showed a significantly lower 5-yr OS compared to NLR = 3.9 (13.5% vs. 36.7%, P < 0.0001). Also PLR >275 was related with a lower 5-yr OS compared to PLR =275 in R+ patients (6.4% vs. 36.8%, P = 0.0003). Conversely, NLR and PLR were irrelevant in case of R0 surgery. Conclusion: NLR and PLR predict 5-yr OS in LRRC, also identifying a subset of R+ patients with a similar expected survival compared to R0 cases. (C) 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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