4.3 Article

SARS-CoV-2 N gene mutations impact detection by clinical molecular diagnostics: reports in two cities in the United States

Journal

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2021.115468

Keywords

SARS-CoV-2 diagnostic testing; Cepheid XpertXpress; COVID-19; SARS-CoV-2; single nucleotide polymorphisms

Funding

  1. Centers for Disease Control and Prevention (CDC) ELC Enhanced Detection grant
  2. University of Pittsburgh COVID Medical Response Office
  3. University of Pittsburgh Medical Center Infection Prevention

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Nasal and nasopharyngeal swab specimens tested by Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites.
Nasal and nasopharyngeal swab specimens tested by the Cepheid Xpert Xpress SARS-CoV-2 were analyzed by whole-genome sequencing based on impaired detection of the N2 target. Each viral genome had at least one mutation in the N gene, which likely arose independently in the New York City and Pittsburgh study sites. (c) 2021 Published by Elsevier Inc.

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