Journal
DIAGNOSTIC CYTOPATHOLOGY
Volume 50, Issue 6, Pages E163-E169Publisher
WILEY
DOI: 10.1002/dc.24941
Keywords
core needle biopsy; cytology; EWSR1; myoepithelial tumor
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Myoepithelial tumors are a group of neoplasms with diverse features, including EWSR1-POU5F1 fusions and aggressive behavior. The cytomorphologic features of these tumors have not been well characterized.
Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.
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