4.7 Review

A novel diabetes typology: towards precision diabetology from pathogenesis to treatment

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

Targeting cardiovascular inflammation: next steps in clinical translation

Patrick R. Lawler et al.

Summary: Systemic vascular inflammation plays crucial roles in the progression and destabilization of ASCVD, requiring more individualized approaches for successful clinical translation. High-sensitivity C-reactive protein may serve as a clinical measure of inflammation.

EUROPEAN HEART JOURNAL (2021)

Article Biochemistry & Molecular Biology

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

Robert Wagner et al.

Summary: Analysis of high-risk individuals revealed six distinct subphenotypes of type 2 diabetes, among which three had elevated glycemia levels, with clusters 3 and 5 having imminent diabetes risks.

NATURE MEDICINE (2021)

Article Endocrinology & Metabolism

Identification of two novel subgroups in patients with diabetes mellitus and their association with clinical outcomes: A two-step cluster analysis

Xiao-fen Xiong et al.

Summary: Seven subgroups of type 2 diabetes were identified in Chinese populations, with distinct characteristics and disparate clinical outcomes. This etiology-based stratification might contribute to the diagnosis and management of type 2 diabetes.

JOURNAL OF DIABETES INVESTIGATION (2021)

Article Endocrinology & Metabolism

Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes

Christian Herder et al.

Summary: A novel clustering approach identified five subgroups of diabetes with distinct progression trajectories of complications, showing multiple differences in biomarkers of inflammation, particularly in severe insulin-resistant diabetes.

DIABETES (2021)

Article Endocrinology & Metabolism

Type 2 Diabetes Subgroups, Risk for Complications, and Differential Effects Due to an Intensive Lifestyle Intervention

Michael P. Bancks et al.

Summary: In this study, researchers found that among overweight and obese adults with type 2 diabetes, lifestyle intervention was associated with differential risk for cardiovascular disease based on diabetes subgroups. Specifically, ILI was associated with increased risk for cardiovascular disease in the poor glucose control subgroup.

DIABETES CARE (2021)

Article Endocrinology & Metabolism

Meta-analyses of Results From Randomized Outcome Trials Comparing Cardiovascular Effects of SGLT2is and GLP-1RAs in Asian Versus White Patients With and Without Type 2 Diabetes

Matthew M. Y. Lee et al.

Summary: This study suggests that Asians may derive greater cardiovascular benefit from SGLT2is in patients with HFrEF and from GLP-1RAs in patients with type 2 diabetes compared to Whites.

DIABETES CARE (2021)

Article Endocrinology & Metabolism

Association of Diabetes Subgroups With Race/Ethnicity, Risk Factor Burden and Complications: The MASALA and MESA Studies

Michael P. Bancks et al.

Summary: This study indicates that there are racial/ethnic differences across diabetes subgroups, and these subgroups also differ in their risk for complications. Strategies to eliminate racial/ethnic disparities in complications may need to consider targeted approaches to diabetes subgroups.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Endocrinology & Metabolism

Glomerular filtration rate decline in T2DM following diagnosis. The Verona newly diagnosed diabetes study-12

Giacomo Zoppini et al.

Summary: This study examined the decline in glomerular filtration rate (GFR) in newly diagnosed type 2 diabetes patients, finding that approximately 1 out of 10 patients experience a rapid decline in GFR. The study identified albuminuria as a strong predictor of rapid GFR decline.

DIABETES RESEARCH AND CLINICAL PRACTICE (2021)

Review Endocrinology & Metabolism

Novel therapies with precision mechanisms for type 2 diabetes mellitus

Leigh Perreault et al.

Summary: The article discusses the development of new drugs for type 2 diabetes mellitus (T2DM) and emphasizes their mechanisms of action and potential for treating T2DM. The number of clinical trials is increasing, providing more personalized and safe treatment options for T2DM patients.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Roderick C. Slieker et al.

Summary: This study investigates the molecular signatures of different clusters of individuals with type 2 diabetes, revealing distinct underlying mechanisms and providing novel biological insights into pancreatic islets, liver, and adipose tissue metabolism. The insulin-resistant cluster showed the most distinct molecular signature, while the obese cluster exhibited higher levels of cytokines. Notably, the mild diabetes cluster with high HDL showed the most beneficial molecular profile.

DIABETES (2021)

Article Endocrinology & Metabolism

Leukocyte Counts and T-Cell Frequencies Differ Between Novel Subgroups of Diabetes and Are Associated With Metabolic Parameters and Biomarkers of Inflammation

Jacqueline M. Ratter-Rieck et al.

Summary: This study revealed distinct leukocyte profiles among different novel diabetes subgroups, suggesting varied inflammatory processes within these diabetes subgroups.

DIABETES (2021)

Article Endocrinology & Metabolism

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

Roderick C. Slieker et al.

Summary: This study replicated and cross-validated five distinct type 2 diabetes clusters using clinical variables in three large cohorts. By substituting C-peptide and HDL-cholesterol for HOMA2 measures, three clusters mapped well to previously identified subtypes. Cross-validation between cohorts showed good resemblance, indicating stability and representativeness of the clusters. Adding HDL-cholesterol resulted in the identification of a cluster with slow glycaemic deterioration progression.

DIABETOLOGIA (2021)

Article Endocrinology & Metabolism

Comparison between data-driven clusters and models based on clinical features to predict outcomes in type 2 diabetes: nationwide observational study

Moa Lugner et al.

Summary: This study did not find evidence to support the existence of a specific number of distinct clusters within type 2 diabetes. The results suggest that a prediction model approach using simple clinical features to predict risk of diabetes complications would be more useful than a cluster sub-stratification.

DIABETOLOGIA (2021)

Review Endocrinology & Metabolism

Toward an Improved Classification of Type 2 Diabetes: Lessons From Research into the Heterogeneity of a Complex Disease

Maria J. Redondo et al.

Summary: Type 2 diabetes (T2D) is phenotypically heterogeneous, requiring an improved etiological classification scheme. Excellent phenotypic descriptions of emerging syndromes in different populations, continued clinical and molecular investigations of atypical forms of diabetes, and useful conceptual models can be utilized to achieve this important goal.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

Article Genetics & Heredity

Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine

Olena Fedotkina et al.

Summary: A novel classification system of adult diabetes into five clusters based on disease pathophysiology and risk of vascular complications was reproducible in a population from northern Ukraine. Patients with long-term diabetes were more prevalent in the severe autoimmune diabetes (SAID) and severe insulin-deficient diabetes (SIDD) clusters. Long-term insulin-resistant obese diabetes 2 (IROD2) cluster exhibited unique characteristics with highest insulin secretion, lowest HbA(1c), and lower prevalence of microvascular complications compared to other clusters. Further investigations are needed to explore the protective mechanisms in this subgroup.

FRONTIERS IN GENETICS (2021)

Article Endocrinology & Metabolism

Clinical Characteristics and Risk of Diabetic Complications in Data-Driven Clusters Among Type 2 Diabetes

Lin Xing et al.

Summary: This study clustered newly diagnosed patients and patients with long-term diabetes into four distinct clusters with significant differences in clinical characteristics, risk of diabetic complications, and medication treatment. Each cluster showed varying prevalence of diabetic complications and utilization of different types of medications.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Clusters of people with type 2 diabetes in the general population: unsupervised machine learning approach using national surveys in Latin America and the Caribbean

Rodrigo M. Carrillo-Larco et al.

Summary: This study used unsupervised machine learning algorithms to cluster people with T2DM in Latin America and the Caribbean, identifying four distinct clusters with unique characteristics and predictors.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

Article Endocrinology & Metabolism

Adult-onset diabetes in Middle Eastern immigrants to Sweden: Novel subgroups and diabetic complications-The All New Diabetes in Scania cohort diabetic complications and ethnicity

Louise Bennet et al.

Summary: Middle Eastern immigrants in Europe have a higher prevalence of severe insulin-deficient diabetes compared to native Swedes, but lower prevalence of severe insulin-resistant diabetes. They also have a higher risk of coronary events but a lower risk of chronic kidney disease, which may be attributed to genetic factors.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2021)

Editorial Material Endocrinology & Metabolism

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

Manuela Battaglia et al.

DIABETES CARE (2020)

Article Biochemistry & Molecular Biology

Molecular Choreography of Acute Exercise

Kevin Contrepois et al.

Article Endocrinology & Metabolism

Clinical characterization of data-driven diabetes subgroups in Mexicans using a reproducible machine learning approach

Omar Yaxmehen Bello-Chavolla et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

Article Biochemistry & Molecular Biology

Human postprandial responses to food and potential for precision nutrition

Sarah E. Berry et al.

NATURE MEDICINE (2020)

Article Endocrinology & Metabolism

Subtypes of Type 2 Diabetes Determined From Clinical Parameters

Emma Ahlqvist et al.

DIABETES (2020)

Review Endocrinology & Metabolism

The clinical consequences of heterogeneity within and between different diabetes types

Maria J. Redondo et al.

DIABETOLOGIA (2020)

Article Endocrinology & Metabolism

Biomarkers of Inflammation and Glomerular Filtration Rate in Individuals with Recent-Onset Type 1 and Type 2 Diabetes

Haifa Maalmi et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Review Environmental Sciences

The Identification of Diabetes Mellitus Subtypes Applying Cluster Analysis Techniques: A Systematic Review

Antonio Sarria-Santamera et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Review Biochemistry & Molecular Biology

The Genetic Basis of Metabolic Disease

Ines Barroso et al.

Article Multidisciplinary Sciences

Risk variants disrupting enhancers of TH1 and TREG cells in type 1 diabetes

Peng Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

A longitudinal big data approach for precision health

Sophia Miryam Schussler-Fiorenza Rose et al.

NATURE MEDICINE (2019)

Meeting Abstract Endocrinology & Metabolism

Novel Subgroups of Type 2 Diabetes at Diagnosis in a Southern European Cohort

Riccardo C. Bonadonna et al.

DIABETES (2019)

Review Endocrinology & Metabolism

Type 2 diabetes: a multifaceted disease

Ewan R. Pearson

DIABETOLOGIA (2019)

Article Endocrinology & Metabolism

Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

Oana P. Zaharia et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

Editorial Material Endocrinology & Metabolism

Heterogeneity of diabetes: heralding the era of precision medicine

Stefano Del Prato

LANCET DIABETES & ENDOCRINOLOGY (2019)

Review Medicine, General & Internal

Precision medicine in type 2 diabetes

R. B. Prasad et al.

JOURNAL OF INTERNAL MEDICINE (2019)

Review Multidisciplinary Sciences

The integrative biology of type 2 diabetes

Michael Roden et al.

NATURE (2019)

Letter Endocrinology & Metabolism

Novel subgroups of patients with adult-onset diabetes in Chinese and US populations

Xiantong Zou et al.

LANCET DIABETES & ENDOCRINOLOGY (2019)

Review Immunology

Targeting innate immune mediators in type 1 and type 2 diabetes

Marc Y. Donath et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Endocrinology & Metabolism

Metabolic Characteristics of Recently Diagnosed Adult-Onset Autoimmune Diabetes Mellitus

Oana P. Zaharia et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Review Endocrinology & Metabolism

Precision medicine in the management of type 2 diabetes

Anna L. Gloyn et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Emma Ahlqvist et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

A Global Overview of Precision Medicine in Type 2 Diabetes

Hugo Fitipaldi et al.

DIABETES (2018)

Review Endocrinology & Metabolism

Painting a new picture of personalised medicine for diabetes

Mark I. McCarthy

DIABETOLOGIA (2017)

Article Cardiac & Cardiovascular Systems

Cohort profile: the German Diabetes Study (GDS)

Julia Szendroedi et al.

CARDIOVASCULAR DIABETOLOGY (2016)

Article Medicine, General & Internal

Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study

Claudia Langenberg et al.

PLOS MEDICINE (2014)

Editorial Material Medicine, General & Internal

Is type 2 diabetes a category error?

Edwin A. M. Gale

LANCET (2013)

Article Endocrinology & Metabolism

Adiponectin Trajectories Before Type 2 Diabetes Diagnosis Whitehall II study

Adam G. Tabak et al.

DIABETES CARE (2012)

Review Endocrinology & Metabolism

The discovery of type 1 diabetes

EAM Gale

DIABETES (2001)