Journal
DIABETES-METABOLISM RESEARCH AND REVIEWS
Volume 38, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/dmrr.3501
Keywords
diabetes mellitus; diabetic ketoacidosis; fulminant; type 1 diabetes
Categories
Funding
- Hunan Province Natural Science Foundation in China [2018JJ2573, 2020JJ2053]
- Hunan Health Commission [202103060904]
- National Key Research and Development Program of China [2016YFC1305000, 2018YFC1315603]
Ask authors/readers for more resources
The study found that the fulminant index (FI), specifically the ratio of K+ to HbA1c (K+/HbA1c), was the most effective indicator for distinguishing FT1D from initial DKA patients.
Aims and Objectives Fulminant type 1 diabetes (FT1D) could present diabetes ketoacidosis (DKA) at early onset. It is crucial to identify FT1D from DKA manifestations in time at clinical practice. This study was aimed at investigating whether the fulminant index (FI), encompassing plasma glucose (PG) to glycated haemoglobin (HbA1c) ratio (PG/HbA1c), serum potassium ion (K+) to HbA1c ratio (K+/HbA1c) and serum sodium ion (Na+) multiplied by HbA1c (Na+*HbA1c), is a feasible indicator for early FT1D diagnosis. Materials and Methods A total of 78 subjects were enroled, including 40 FT1D patients and 38 non-FT1D patients with DKA. We utilised receiver operating characteristic (ROC) curve analysis to determine the FI cut-off values between FT1D and non-FT1D groups and examined efficacies of FI based on statistics. Results ROC curve analyses showed that the maximum Youden's index for PG/HbA1c bonding to a cut-off value of 4.389, with the sensitivity of 75.0% and specificity of 81.6% in identifying FT1D from DKA. And optimal K+/HbA1c cut-off value was 0.728 with a sensitivity of 90.0% and specificity of 84.2%. For Na+*HbA1c, the best cut-off value was 923.65, and its sensitivity and specificity were 85% and 73.7%, respectively. Conclusions These results suggested FI could work as a valid and convenient indicator for differentiating FT1D from initial DKA patients. FI (K+/HbA1c) presented the best efficacy as an independent index.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available