Journal
DIABETES CARE
Volume 45, Issue 1, Pages 23-27Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dci21-0012
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Funding
- Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)
- Clinical Center, NIH
- NIH [UC4DK116284-03, U01DK104218-03]
- JDRF [5-COE-2020-967-M-N]
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This article recounts the glorious history of insulin research, telling the stories of passionate scientists pursuing groundbreaking research. The fruits of their labor include Nobel Prizes and new technology, which have played a crucial role in improving treatments for diabetes.
Since diabetes was first described over 3,000 years ago, clinicians and scientists alike have sought ever improving treatments en route to a cure. As we approach the 100th anniversary of insulin's first therapeutic use, this article will recount the glorious history associated with research surrounding insulin's isolation, purification, cloning, and subsequent modification. The discovery path we will relate tells the story of many relentless and passionate investigators pursuing groundbreaking research. The fruits of their labor include several Nobel Prizes, new technology, and, more importantly, ever improving treatments for one of humankind's greatest medical scourges.
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