The importance of long-lived proteins: Not just nuclear anymore

The significance of mitochondrial long-lived proteins (mitoLLPs) to tissue health has remained mysterious for over a decade. In this issue of Developmental Cell, Krishna et al. demonstrate that mitochondrial lifetimes are highly heterogeneous and that mitoLLPs promote respiratory capacity by facilitating supercomplex assembly within the electron transport chain.

Automated summary

Research has found that mitochondrial long-lived proteins (mitoLLPs) play a significant role in promoting respiratory capacity by facilitating supercomplex assembly within the electron transport chain, thus improving mitochondrial efficiency.