4.4 Article

Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart

Related references

Note: Only part of the references are listed.
Article Cell Biology

Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

Xiangwen Peng et al.

Summary: The study found that after cardiac injury in zebrafish, the expression of secreted Wnt inhibitors is induced in the cardiac tissue, blocking Wnt signaling pathway can promote cardiomyocyte proliferation and heart regeneration, whereas activation of Wnt8 signaling pathway inhibits injury-induced cardiomyocyte dedifferentiation and proliferation.

JOURNAL OF MOLECULAR CELL BIOLOGY (2021)

Article Developmental Biology

Is zebrafish heart regeneration complete? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts

Alberto Bertozzi et al.

Summary: Adult zebrafish can completely regenerate pre-injury cardiomyocyte numbers through proliferation after cryoinjury, but a subset of regenerated cardiomyocytes fail to fully mature. Furthermore, there is no evidence of cardiomyocyte transdifferentiation into non-myocyte cell lineages such as endothelial, epicardial, fibroblast or immune cells.

DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Kruppel-like factor 1 is a core cardiomyogenic trigger in zebrafish

Masahito Ogawa et al.

Summary: Our research identified Klf1 as a key transcriptional regulator of cardiomyocyte renewal in adult zebrafish hearts, supporting myocardial expansion through epigenetic reprogramming and rewiring of mitochondrial metabolism.

SCIENCE (2021)

Article Cell Biology

Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair

Shuying Xie et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Generic wound signals initiate regeneration in missing-tissue contexts

Suthira Owlarn et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish

Daniel Wehner et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Wnt/β-catenin signaling promotes regeneration after adult zebrafish spinal cord injury

Nicholas S. Strand et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Developmental Biology

Wnt-regulated dynamics of positional information in zebrafish somitogenesis

Lola Bajard et al.

DEVELOPMENT (2014)

Article Biochemical Research Methods

High-resolution reconstruction of the beating zebrafish heart

Michaela Mickoleit et al.

NATURE METHODS (2014)

Article Cell Biology

The beta-Catenin Destruction Complex

Jennifer L. Stamos et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling and Disease

Hans Clevers et al.

Article Cell & Tissue Engineering

Developmental Stage and Time Dictate the Fate of Wnt/β-Catenin-Responsive Stem Cells in the Mammary Gland

Renee van Amerongen et al.

CELL STEM CELL (2012)

Article Cardiac & Cardiovascular Systems

Hypoxia Induces Myocardial Regeneration in Zebrafish

Chris Jopling et al.

CIRCULATION (2012)

Article Developmental Biology

In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains

Enrico Moro et al.

DEVELOPMENTAL BIOLOGY (2012)

Article Developmental Biology

β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina

Jason R. Meyers et al.

NEURAL DEVELOPMENT (2012)

Article Cell Biology

Frizzled and LRP5/6 Receptors for Wnt/β-Catenin Signaling

Bryan T. MacDonald et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Article Cell Biology

TCF/LEFs and Wnt Signaling in the Nucleus

Ken M. Cadigan et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Article Developmental Biology

The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

Fabian Chablais et al.

BMC DEVELOPMENTAL BIOLOGY (2011)

Article Developmental Biology

Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish

Juan Manuel Gonzalez-Rosa et al.

DEVELOPMENT (2011)

Article Cell Biology

Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin

Franziska Knopf et al.

DEVELOPMENTAL CELL (2011)

Article Biochemical Research Methods

In vivo protein trapping produces a functional expression codex of the vertebrate proteome

Karl J. Clark et al.

NATURE METHODS (2011)

Article Cardiac & Cardiovascular Systems

Active Wnt signaling in response to cardiac injury

Martinus I. F. J. Oerlemans et al.

BASIC RESEARCH IN CARDIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway

Alok S. Pachori et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)

Article Multidisciplinary Sciences

Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes

Kazu Kikuchi et al.

NATURE (2010)

Article Cell Biology

O2 regulates stem cells through Wnt/β-catenin signalling

Jolly Mazumdar et al.

NATURE CELL BIOLOGY (2010)

Review Cell Biology

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

Bryan T. MacDonald et al.

DEVELOPMENTAL CELL (2009)

Article Cell Biology

The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo

Vitezslav Bryja et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Biochemistry & Molecular Biology

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Baozhi Chen et al.

NATURE CHEMICAL BIOLOGY (2009)

Review Cell Biology

Proximal events in Wnt signal transduction

Stephane Angers et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells

Shuichi Ueno et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Developmental Biology

Distinct Wnt signaling pathways have opposing roles in appendage regeneration

Cristi L. Stoick-Cooper et al.

DEVELOPMENT (2007)

Review Biochemistry & Molecular Biology

β-Catenin destruction complex:: insights and questions from a structural perspective

D. Kimelman et al.

ONCOGENE (2006)

Review Biochemistry & Molecular Biology

Function and biological roles of the Dickkopf family of Wnt modulators

C. Niehrs

ONCOGENE (2006)

Article Biochemistry & Molecular Biology

The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes

Ai-Sun Tseng et al.

CHEMISTRY & BIOLOGY (2006)

Article Developmental Biology

T-box binding sites are required for activity of a cardiac GATA-4 enhancer

A Heicklen-Klein et al.

DEVELOPMENTAL BIOLOGY (2004)

Review Genetics & Heredity

WNT and β-catenin signalling:: Diseases and therapies

RT Moon et al.

NATURE REVIEWS GENETICS (2004)

Article Biochemistry & Molecular Biology

DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway

A Niida et al.

ONCOGENE (2004)

Review Biochemistry & Molecular Biology

Wnt proteins induce dishevelled phosphorylation via an LRP5/6-Independent mechanism, irrespective of their ability to stabilize β-catenin

JM González-Sancho et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Cell Biology

The Wnt signaling pathway in development and disease

CY Logan et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)

Review Cell Biology

GSK-3: tricks of the trade for a multi-tasking kinase

BW Doble et al.

JOURNAL OF CELL SCIENCE (2003)

Article Multidisciplinary Sciences

Heart regeneration in zebrafish

KD Poss et al.

SCIENCE (2002)

Article Developmental Biology

In vivo imaging of embryonic vascular development using transgenic zebrafish

ND Lawson et al.

DEVELOPMENTAL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Negative feedback loop of Wnt signaling through upregulation of conductin/Axin2 in colorectal and liver tumors

B Lustig et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

EH Jho et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Article Multidisciplinary Sciences

Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors

D Yan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling

W Wu et al.

CURRENT BIOLOGY (2000)