Journal
DERMATOLOGIC THERAPY
Volume 35, Issue 3, Pages -Publisher
WILEY-HINDAWI
DOI: 10.1111/dth.15284
Keywords
adalimumab; immune response; methotrexate; microbiology; psoriasis
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Funding
- Novo Nordic Foundation
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Methotrexate has minimal effect on cytokine responses, while adalimumab affects a wide range of cytokines involved in immune defense. The cytokine levels in patients receiving long-term adalimumab treatment are almost equivalent to those receiving short-term treatment.
Patients with psoriasis are commonly treated with methotrexate or biologics. We examined the immune response in a whole blood assay (TruCulture (R)) to assess the effect of methotrexate and adalimumab. Twenty patients with psoriasis were included and cytokine levels following stimulation with LPS, R848, HKCA, PolyIC, or a blank were investigated before and after 3-6 months of treatment with methotrexate or adalimumab and in patients who had received adalimumab >5 years. Methotrexate only induced minor changes in the cytokine responses, whereas adalimumab affected a wide range of cytokines important for the immune defense towards microorganisms. In the long-term adalimumab treated group, the cytokine levels were almost equivalent to the short-term adalimumab-treated group. Overall, methotrexate was not associated with cytokine suppression. Short and long-term treatment with adalimumab lowered multiple cytokines involved in the immune defense equally emphasizing the need to continuously be aware of the risk of infections in these patients.
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