A review of reported infectious events following rituximab therapy in pemphigus patients

Pemphigus is a rare autoimmune blistering condition that used to be fatal before the introduction of corticosteroid (CS) and immunosuppressive agents. Rituximab is a monoclonal anti-CD-20 antibody that induces the pathologic B-cells apoptosis with significant efficacy in the treatment of pemphigus. The application of rituximab can lead to infectious events. We aim to review the reported infectious events in pemphigus patients who previously received rituximab and classify them based on the causative agents. A thorough search of PubMed was conducted using the keywords rituximab, pemphigus, infection, viral disease, viral infection, complication, efficacy and their combinations also applying their equivalent Mesh terms and including the references cited in each study. All studies that mentioned at least one infectious event were included. A total of 77 infectious events in 68 patients were reported in the literature out of which the most reported causative agent was viral but the most fatal one found to be bacterial. Although rituximab therapy has shown promising results in controlling pemphigus patients mainly the refractory cases, given possible fatal outcomes, we believe the medical profile of the patients before initiating the therapy warrants careful examination to search for any risk factors or predisposing conditions.

Automated summary

Rituximab has shown significant efficacy in treating pemphigus patients but can lead to infectious events, among which viral agents are most commonly reported while bacterial agents are found to be the most fatal. Careful evaluation of the patients' medical profile before initiating rituximab therapy is necessary to identify any potential risk factors or predisposing conditions.