Journal
DENTAL MATERIALS JOURNAL
Volume 41, Issue 2, Pages 189-196Publisher
JAPANESE SOC DENTAL MATERIALS DEVICES
DOI: 10.4012/dmj.2021-205
Keywords
Anti-biofilm effect; Antibacterial activity; Protein; MDPB; MPC
Funding
- Japan Society for the Promotion of Science [JP16K15800]
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The copolymer combining protein-repellent and antibacterial agents showed long-lasting effects in terms of protein repulsion, antibacterial activity, and anti-biofilm formation.
The provision of antibacterial properties to resinous restorative/reconstructive materials by incorporating polymerizable bactericides such as 12-methacryloyloxydodecylpyridinium bromide (MDPB) has been attempted. Previously, MDPB was combined with 2-methacryloyloxyethyl phosphorylcholine (MPC) to fabricate a copolymer coating to increase antibacterial effectiveness by protein repelling. In this study, we assessed the longevity of the protein-repelling, antibacterial, and antibiofilm effects of the MDPB-MPC copolymer. After 28 days of water immersion, MPC-containing copolymers exhibited lower adsorption of bovine serum albumin and salivary proteins; after 24 h of incubation, MDPB-containing copolymers demonstrated antibacterial effects against Streptococcus mutans. The copolymer containing both MDPB and MPC showed thinner biofilm formation with a higher percentage of membrane-compromised bacteria than control. The results were consistent with those before aging, indicating the long-lasting antibacterial, protein-repellent, and antibiofilm effects of this copolymer. The durable copolymer developed in this study can be applied to dental resins to control bacteria in the oral environment.
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