Journal
CYTOKINE
Volume 146, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2021.155624
Keywords
Cytokine; IL-6; IL-6 Signaling; JAK; STAT; M1 cells
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Interleukin 6, a pleiotropic cytokine, plays a critical role in immune responses, inflammation, and haematopoiesis by triggering activation of the JAK/STAT signaling cascade in cells. Studies utilizing the M1 cell line have contributed to our understanding of the molecular mechanisms governing IL-6 signaling.
Interleukin 6 is the classical member of the IL-6 family of cytokines which triggers activation of the JAK/STAT signaling cascade in cells. IL-6 is a pleiotropic cytokine that acts on many cell types and plays a critical role in immune responses, inflammation, and haematopoiesis. Our understanding of the molecular mechanisms governing IL-6 signaling has been aided by numerous studies of this signal transduction pathway, including those utilising the M1 cell line. Here we discuss the studies that we and others have undertaken using the M1 line to examine IL-6 inducible genes, particularly those targets that acts as negative regulators of signaling. Finally, we present a model for the current understanding of the IL-6 signaling pathway at a structural and mechanistic level.
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