Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 22, Issue 14, Pages 1177-1188Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026621666211214151534
Keywords
Indazole derivatives; Cardiovascular diseases; Molecular mechanism; Cardiomyopathy; Drug discovery; N; sativa
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Funding
- Department of Biotechnology [BT/PR22881/BRB/10/1654/2018]
- National Institute of Health [NIHR01HL152132]
- ICMR RA fellowship [3/1/2(19)/OBS/2019-NCD-II]
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This review summarizes the structural and pharmacological functions of indazole derivatives that have shown efficacy against cardiovascular pathologies in experimental settings.
Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.
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