Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 28, Issue 12, Pages 1011-1018Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612827666211210123959
Keywords
H19; long noncoding RNA; miRNA; treatment; hyperglycemia; diabetes; diabetic complications
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Funding
- National Natural Science Foundation of China [81773959, 81974528, 82174035, 2020ZYYD016]
- central government guides the special funds for the development of local science and technology [2020ZYYD016]
- innovational group project of Hubei Province Natural Science Foundation in China [2021CFA015]
- Health commission of Hubei Province scientific research project in China [WJ2019H527]
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This review explores the functions and mechanisms of long noncoding RNA H19 in diabetes mellitus and diabetic complications and highlights its potential as an instructive marker for the treatment of diabetes mellitus.
Background: Increasing academic efforts have been made to explore the correlation of long noncoding RNAs (lncRNAs) with human diseases, particularly metabolic diseases like diabetes mellitus. Taking lncRNA H19 as an example, this review intends to reveal the functions and mechanism of lncRNA H19 in diabetes mellitus and diabetic complications. Methods: The research results associated with lncRNA H19 and diabetes mellitus are collected and summarized on PubMed. Conclusion: LncRNA H19 is a potential instructive marker for the treatment of diabetes mellitus and diabetic complications.
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